Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-048-3343   Email: info@creative-biomart.com
Home > Products > Assay Kits > Activity Kits > Cyclooxygenase 1 Inhibitor Screening Fluorometric Kit

Cyclooxygenase 1 Inhibitor Screening Fluorometric Kit

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Cat.No.:
Kit-0256
Product Overview:
Cyclooxygenase 1 (COX1) Inhibitor Screening Kit (Fluorometric) offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of COX-1 inhibitors. The assay is based on the fluorometric detection of Prostaglandin G2, the intermediate product generated by the COX enzyme.
Size:
100 tests
Description:
Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS, EC 1.14.99.1), is an enzyme that is responsible for the formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. COX is the central enzyme in the biosynthetic pathway to prostanoids from arachidonic acid. There are two known isoenzymes: COX-1 and COX-2. COX-1 is constitutively expressed in many tissues and is the predominant form in gastric mucosa and in kidney. COX-2 is not expressed under normal conditions in most cells, but elevated levels are found during inflammation. Pharmacological inhibition of COX by nonsteroidal anti-inflammatory drugs (NSAID) can provide relief from the symptoms of inflammation and pain.
Applications:
Inhibition Assaymore details
Target Species:
Reacts with: Species independent
Storage:
Store at -20°C.
Kit Components:
Components: 100 tests; Arachidonic Acid: 1 x 50µl; COX Assay Buffer: 1 x 25ml; COX Cofactor (in DMSO): 1 x 20µl; COX Probe (in DMSO): 1 x 200µl; COX-1, Ovine: 1 vial; NaOH: 1 x 500µl; SC560, COX-1 inhibitor (in DMSO): 1 x 100µl
Detection method:
Fluorescent
Compatible Sample Types:
Inhibitor compounds


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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