|Product Overview:||This kit can be used for screening of DPP4 inhibitors. (100 assays)|
|Description:||Dipeptidyl peptidase-4 (DPP4) inhibitors have emerged as a new class of oral antidiabetic agents. These inhibitors promote glucose homeostasis by inhibiting degradation of glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 by DPP4. Glucagon-like peptide-1 extends the action of insulin while suppressing the release of glucagon. In DPP4 Inhibitor Screening Kit, DPP4 cleaves a substrate to release a quenched fluorescent group (Em/Ex = 360/460 nm). In presence of a DPP4 inhibitor, the cleavage will be inhibited. The kit provides a rapid, simple, sensitive, and reliable test, as well as, suitable for high throughput screening of DPP4 inhibitors. Sitagliptin is included as a control inhibitor to compare the efficacy of the test inhibitors.|
|Usage:||This product is furnished for LABORATORY RESEARCH USE ONLY. Not for diagnostic or therapeutic use.|
|Kit Components:||DPP4 Assay BufferDPP4 SubstrateDPP4 EnzymeDPP4 Inhibitor (Sitagliptin)|
|Detection method:||Fluorescence Plate ReaderFluorometer|
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