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Dihydrofolate Reductase Inhibitor Screening Kit

Cat.No. : Kit-2100
Product Overview : Dihydrofolate Reductase Inhibitor Screening Kit is designed for screening DHFR inhibitors. MTX is used as a positive control. The DHFR activity is monitored by the reduction in absorbance reading at OD340 nm, while potential inhibitors arrest this decrease. The kit is adapted to a 96-well format and provides a rapid, simple, sensitive, and reliable test for high-throughput screening of DHFR inhibitors.
  • Specification
  • Gene Information
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Size : 100 assays
Applications : Screening/characterizing/studying ACE2 inhibitors/activators
Storage : Upon receiving the kit, store DHFR Substrate at -80°C. Store other components at -20°C. Briefly centrifuge small vials prior to opening. Read entire protocol before performing the assay. Upon opening, use within two months.DHFR Assay Buffer: Warm to room temperature before use. Store at 4°C or -20°C.DHFR Substrate: Aliquots and store at -80°C, protect from light. Avoid repeated freeze/thaw.Dihydrofolate Reductase: Store at –20°C. Avoid repeated freeze/thaw. Keep on ice while in use.NADPH: Reconstitute with 200 μl DHFR Assay Buffer to generate NADPH Stock Solution. Aliquot and store at –20°C. Keep on ice while in use.Methotrexate: Aliquot and store at -20°C. Protect from light. Keep at room temperature while in use.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you name a common DHFR inhibitor drug used in cancer treatment? 03/12/2020

Methotrexate is a common DHFR inhibitor drug used in cancer treatment.

Are there ongoing research efforts to develop new DHFR inhibitors for clinical use? 02/21/2018

Yes, scientists continue to research and develop new DHFR inhibitors with improved efficacy and reduced side effects for various clinical applications.

Are there any drug-resistant strains that have developed due to DHFR inhibitors? 12/06/2017

Yes, drug-resistant strains have emerged due to mutations in DHFR genes, reducing the effectiveness of DHFR inhibitor drugs.

Are there any side effects associated with DHFR inhibitor drugs like Methotrexate? 11/28/2017

Yes, common side effects of DHFR inhibitors include nausea, vomiting, decreased blood cell counts, and liver toxicity.

Can you name an antibiotic that inhibits DHFR in bacteria? 11/21/2016

Trimethoprim is an antibiotic that inhibits DHFR in bacteria.

Customer Reviews (3)

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Reviews
04/16/2023

    The DHFR protein offered by the manufacturer is of exceptional quality, making it an ideal choice to fulfill my experimental needs.

    03/20/2017

      Another crucial aspect where the manufacturer excels is their efficient supply chain management.

      08/31/2016

        The technical support provided by the manufacturer is invaluable in overcoming experimental hurdles and optimizing the utilization of DHFR protein.

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