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Active GMP Recombinant Human CSF2 Protein

Cat.No. : CSF2-149HG
Product Overview : Recombinant Human CSF2 (Ala18-Glu144) with a 6His tag at the C-terminus was produced in HEK293 cell in an animal component free process under cGMP guidelines.
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  • Gene Information
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Description : Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic, monocytes/ macrophages and eosinophils. GM-CSF has a functional role on non-hematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines.
Source : HEK293 cell
Species : Human
Form : Lyophilized.
Bio-activity : Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells.
The ED50 for this effect is typically 0.014-0.125 ng/ml.
AA Sequence : APARSPSPSTQPWEHVNAIQEARRL LNLSRDTAAEMNETVEVISEMFDLQ EPTCLQTRLELYKQG LRGSLTKLKGPLTMMASHYKQHCPP TPETSCATQIITFESFKENLKDFLL VIPFDCWEPVQEVDH HHHHH
Residual Host Cell DNA Content_ : <10pg/mg
Residual Host Cell Protein Content_ : <1ug/mg
Endotoxin : <0.1EU/ug
Purity : Greater than 95% as determined by reducing SDS-PAGE.
Storage : Lyophilized and reconstituted protein should be stored at -80 centigrade. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Reconstitution : Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration >100μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Quality Statement : Our GMP proteins are produced according to relevant sections of the following documents: WHO TRS, No. 822, 1992 Annex 1, Good Manufacturing Practices for Biological Products; USP Chapter 1043, Ancillary Materials for Cell, Gene and Tissue-Engineered Products and USP Chapter 92, Growth Factors and Cytokines Used in Cell Therapy Manufacturing.
Shipping : The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.
Gene Name : CSF2 colony stimulating factor 2 (granulocyte-macrophage) [ Homo sapiens ]
Official Symbol : CSF2
Synonyms : CSF2; granulocyte-macrophage colony-stimulating factor; GM CSF; GMCSF; granulocyte macrophage colony stimulating factor; molgramostin; sargramostim; CSF; colony-stimulating factor
Gene ID : 1437
mRNA Refseq : NM_000758
Protein Refseq : NP_000749
MIM : 138960
UniProt ID : P04141

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How conserved is the sequence of CSF2 among different species? 05/15/2021

The sequence of CSF2 is moderately conserved across different species.

What is the typical length of CSF2? 01/30/2021

The length of CSF2 protein varies but is typically around 144 amino acids.

What is the main biological function of CSF2? 05/01/2019

The primary function of CSF2 is to regulate the production and differentiation of white blood cells.

In what tissues or cells is CSF2 commonly expressed? 02/03/2019

CSF2 is often expressed in immune cells, specifically in macrophages, T cells, and endothelial cells.

What does CSF2 stand for? 07/10/2018

CSF2 stands for Colony Stimulating Factor 2.

Is CSF2 associated with any specific diseases or conditions? 03/17/2018

CSF2 dysregulation has been linked to autoimmune diseases and inflammatory disorders.

Which cellular functions are associated with CSF2? 02/20/2017

CSF2 is involved in the stimulation of stem cells to produce granulocytes and monocytes.

Customer Reviews (3)

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Reviews
01/15/2022

    The product's adherence to regulatory standards aligned with our lab's commitment to responsible and transparent research.

    07/27/2021

      The manufacturer's commitment to meeting regulatory requirements demonstrated its dedication to ethical research practices.

      05/19/2019

        Compliance with industry standards minimized potential roadblocks in securing approvals for our experiments.

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