GMP Recombinant Human CTLA4 Protein
Cat.No. : | CTLA4-155HG |
Product Overview : | Recombinant Human CTLA4 (Lys36-Asp161) with a Fc tag at the C-terminus was produced in HEK293 cell in an animal component free process under cGMP guidelines. |
- Specification
- Gene Information
- Related Products
Description : | Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily. Human or mouse CTLA4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence, a 126 aa extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane (TM) sequence, and a 41 aa cytoplasmic sequence.It is widely expressed with highest levels in lymphoid tissues. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4. |
Source : | HEK293 cell |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized. |
AA Sequence : | KAMHVAQPAVVLASSRGIASFVCEY ASPGKATEVRVTVLRQADSQVTEVC AATYMMGNELTFLDD SICTGTSSGNQVNLTIQGLRAMDTG LYICKVELMYPPPYYLGIGNGTQIY VIDPEPCPDSDQEPK SSDKTHTSPPSPAPELLGGSSVFLF PPKPKDTLMISRTPEVTCVVVDVSH EDPEVKFNWYVDGVE VHNAKTKPREEQYNSTYRVVSVLTV LHQDWLNGKEYKCKVSNKALPAPIE KTISKAKGQPREPQV YTLPPSRDELTKNQVSLTCLVKGFY PSDIAVEWESNGQPENNYKTTPPVL DSDGSFFLYSKLTVD KSRWQQGNVFSCSVMHEALHNHYTQ KSLSLSPGK |
Residual Host Cell DNA Content : | <10pg/mg |
Residual Host Cell Protein Content : | <1ug/mg |
Endotoxin : | <0.1EU/ug |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Usage : | Recommemnd working concentration: 10-100ug/ml |
Storage : | Lyophilized and reconstituted protein should be stored at -80 centigrade. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration >100μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Quality Statement : | Our GMP proteins are produced according to relevant sections of the following documents: WHO TRS, No. 822, 1992 Annex 1, Good Manufacturing Practices for Biological Products; USP Chapter 1043, Ancillary Materials for Cell, Gene and Tissue-Engineered Products and USP Chapter 92, Growth Factors and Cytokines Used in Cell Therapy Manufacturing. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Gene Name : | CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ] |
Official Symbol : | CTLA4 |
Synonyms : | CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; CD28; CD152; GSE; ICOS; CD152 isoform; celiac disease 3; cytotoxic T-lymphocyte antigen 4; GRD4; CTLA-4; IDDM12; CELIAC3 |
Gene ID : | 1493 |
mRNA Refseq : | NM_001037631 |
Protein Refseq : | NP_001032720 |
UniProt ID : | P16410 |
Products Types
◆ Recombinant Protein | ||
CTLA4-109C | Active Recombinant Cynomolgus/Rhesus CTLA4 protein(Met1-Asp161), His-tagged | +Inquiry |
CTLA4-2073P | Recombinant CTLA4 Protein, His-Flag-StrepII-tagged | +Inquiry |
CTLA4-869H | Recombinant Human CTLA4 Protein, His&GST-tagged | +Inquiry |
CTLA4-657R | Recombinant Rat CTLA4 Protein, Fc-tagged | +Inquiry |
CTLA4-653M | Recombinant Mouse CTLA4 Protein | +Inquiry |
◆ Lysates | ||
CTLA4-2179MCL | Recombinant Mouse CTLA4 cell lysate | +Inquiry |
CTLA4-2526HCL | Recombinant Human CTLA4 cell lysate | +Inquiry |
CTLA4-1047CCL | Recombinant Cynomolgus CTLA4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1713 | CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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