GMP Recombinant Human IFNG protein
Cat.No. : | IFNG-4347HG |
Product Overview : | Recombinant Human IFNG protein was expressed in Escherichia coli. This product is produced under cGMP guidelines. |
- Specification
- Gene Information
- Related Products
Description : | Interferon-gamma (IFN-γ), also known as Type II interferon or immune interferon, is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α family proteins. Mature IFN-γ exists as noncovalently-linked homodimers. Human IFN-γ is highly species specific and is biologically active only in human and primate cells. IFN-γ was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-γ induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN-γ also augments TH1 cell expansion and may be required for TH1 cell differentiation. |
Source : | E.coli |
Species : | Human |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 5.0, with 3 % Trehalose. |
Bio-activity : | Fully biologically active when compared to standard. The ED50 as measured in anti-viral assays using human HeLa cells infected with encephalomyocarditis (EMC) virus is 0.15-0.80 ng/ml. |
Molecular Mass : | Approximately 16.9 kDa, a single non-glycosylated polypeptide chain containing 144 amino acids. |
Protein length : | 144 |
AA Sequence : | MQDPYVKEAENLKKYFNAGHSDVAD NGTLFLGILKNWKEESDRKIMQSQI VSFYFKLFKNFKDDQSIQKSVETIK EDMNVKFFNSNKKKRDDFEKLTNYS VTDLNVQRKAIHELIQVMAELSPAA KTGKRKRSQMLFRGRRASQ |
Endotoxin : | Less than 0.01 EU/µg of rHuIFN-γ GMP as determined by LAL method. |
Purity : | >98% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | IFNG |
Official Symbol : | IFNG |
Synonyms : | IFNG; interferon, gamma; interferon gamma; IFN-gamma; immune interferon; IFG; IFI; |
Gene ID : | 3458 |
mRNA Refseq : | NM_000619 |
Protein Refseq : | NP_000610 |
MIM : | 147570 |
UniProt ID : | P01579 |
Products Types
◆ Recombinant Protein | ||
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IFNG-8549H | Active Recombinant Human IFNG protein(Met1-Gln166) | +Inquiry |
IFNG-497H | Recombinant Human IFNG Protein | +Inquiry |
IFNG-119H | Recombinant Active Human IFNG Protein, His-tagged(C-ter) | +Inquiry |
IFNG-105I | Active Recombinant Human IFNG Protein (144 aa) | +Inquiry |
◆ Lysates | ||
IFNG-1007FCL | Recombinant Ferret IFNG cell lysate | +Inquiry |
IFNG-1797MCL | Recombinant Mouse IFNG cell lysate | +Inquiry |
IFNG-001HCL | Recombinant Human IFNG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIFNG plays an important role in tumor immunotherapy, which can activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.
The development of drugs for IFNG is currently in clinical trials, including monoclonal antibodies against IFNG receptors and inhibitors against IFNG signaling pathways.
Studies have shown that IFNG can inhibit the occurrence of muscle atrophy, but the specific mechanism is not clear.
In clinical practice, the expression level of IFNG can be measured to predict the progression and prognosis of the disease, and to guide the choice of treatment regimen.
Yes, there are other coding variants in the IFNG gene that may have different functions and expression patterns.
Such as nutritional status, inflammation levels, etc. Yes, the expression of IFNG is affected by environmental factors, such as nutritional status, inflammation level, etc.
Customer Reviews (3)
Write a reviewIt is analyzed by X-ray crystallography or other crystallization techniques and has good crystallization properties.
Easy to attach to the surface of cells or materials.
IFNG products have a complete range of specifications for experimental designs of different sizes and needs.
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