Active GMP Recombinant Human IL2 Protein
Cat.No. : | IL2-152HG |
Product Overview : | Recombinant Human IL2 (Ala21-Thr153) with a 6His tag at the C-terminus was produced in HEK293 cell in an animal component free process under cGMP guidelines. |
- Specification
- Gene Information
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Description : | Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system,belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. |
Source : | HEK293 cell |
Species : | Human |
Form : | Lyophilized. |
Bio-activity : | Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is typically 0.02-0.3ng/mL. Specific Activity of 1.0 x 10^7 IU/mg. |
AA Sequence : | APTSSSTKKTQLQLEHLLLDLQMIL NGINNYKNPKLTRMLTFKFYMPKKA TELKHLQCLEEELKP LEEVLNLAQSKNFHLRPRDLISNIN VIVLELKGSETTFMCEYADETATIV EFLNRWITFCQSIIS TLTVDHHHHHH |
Residual Host Cell DNA Content : | <10pg/mg |
Residual Host Cell Protein Content : | <1ug/mg |
Endotoxin : | <0.1EU/ug |
Purity : | Greater than 95% as determined by reducing SDS-PAGE. |
Usage : | Recommemnd working concentration: 30ng/ml or 300U/ml |
Storage : | Lyophilized and reconstituted protein should be stored at -80 centigrade. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Reconstitution : | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration >100μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Quality Statement : | Our GMP proteins are produced according to relevant sections of the following documents: WHO TRS, No. 822, 1992 Annex 1, Good Manufacturing Practices for Biological Products; USP Chapter 1043, Ancillary Materials for Cell, Gene and Tissue-Engineered Products and USP Chapter 92, Growth Factors and Cytokines Used in Cell Therapy Manufacturing. |
Shipping : | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Gene Name : | IL2 interleukin 2 [ Homo sapiens ] |
Official Symbol : | IL2 |
Synonyms : | IL2; interleukin 2; interleukin-2; IL 2; T cell growth factor; TCGF; aldesleukin; IL-2; lymphokine |
Gene ID : | 3558 |
mRNA Refseq : | NM_000586 |
Protein Refseq : | NP_000577 |
MIM : | 147680 |
UniProt ID : | P60568 |
Products Types
◆ Recombinant Protein | ||
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IL2-02H | Active Recombinant Human IL2 Protein (Ala21-Thr153), Biotinylated | +Inquiry |
IL2-154C | Active Recombinant Canine IL2 Protein | +Inquiry |
IL2-169H | Active Recombinant Human IL2 Protein, His-tagged(C-ter) | +Inquiry |
IL2-1118H | Recombinant Human IL2 Protein (Ala21-Thr153), Biotinylated | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionIL2 promotes the formation of memory T-cells.
IL2 has a pro-tumorigenic role in the tumor microenvironment.
IL2 synergizes with IL-12 in a mixed cytokine environment.
IL2 upregulates the expression of PD-1 checkpoint inhibitors.
IL2 is rapidly internalized by activated T-cells.
IL2 induces M1 macrophage polarization.
IL2 increases blood-brain barrier permeability.
IL2's affinity for its receptor decreases under hypoxic conditions.
IL2's bioactivity is enhanced by glycosylation.
IL2 promotes the differentiation of Th17 cells.
Customer Reviews (3)
Write a reviewPotent in T-cell activation.
Suitable for cytokine assays.
High stability.
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