Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-048-3343   Email:
Home > Products > Assay Kits > Activity Kits > HAT Inhibitor Screening Assay Kit
"HAT" Related Products.
Product Overview:
HAT Inhibitor Screening Assay Kit is a fluorescence-based method for screening pCAF HAT inhibitors.
DNA is organized into a nucleoprotein complex termed chromatin, which not only is involved with the compaction of DNA within the nucleus but also serves as an important means to regulate genome function. The basic unit of chromatin is the nucleosome. Each nucleosome core contains two molecules each of the core histones H2A, H2B, H3, and H4. Almost two turns of DNA are wrapped around this octameric core, which represses transcription. The histone amino termini extend from the core, where they can be modified post-translationally by acetylation, phosphorylation, ubiquitination, and methylation, affecting their charge and function. Acetylation of the ε-amino groups of specific histone lysine residues, is catalyzed by histone acetyltransferases (HATs) producing a histone modification that correlates with an open chromatin structure and gene activation. Histone deacetylases (HDACs) catalyze the hydrolytic removal of acetyl groups from histone lysine residues and correlates with chromatin condensation and transcriptional repression. Functional defects of either of these enzymes can lead to several diseases, ranging from cancer to neurodenerative dieases. HATs and HDACs thus are potential therapeutic targets.
For research use only (RUO)
This kit will perform as specified if stored at -20°C and used before the expiration date indicated on the outside of the box.
Kit Components:
HAT Assay Buffer (5X) 1 vialHAT Acetyl CoA 1 vialHistone Acetyltransferase (pCAF) 1 vialHAT Peptide 1 vialHAT Stop Reagent 1 vialHAT Developer 1 vial96-Well Plate (white) 1 plate96-Well Cover Sheet 1 cover

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Note: There will be extra charge for optional service!
Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127

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