Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-048-3343   Email: info@creative-biomart.com
Home > Products > Assay Kits > Epigenetic Kits > HDAC1 Inhibitor Screening Assay Kit

HDAC1 Inhibitor Screening Assay Kit

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Cat.No.:
Kit-0429
Product Overview:
HDAC1 Inhibitor Screening Assay Kit is a fluorescence-based method for screening HDAC1 inhibitors.
Description:
Nucleosomes, which fold chromosomal DNA, contain two molecules each of the core histones H2A, H2B, H3, and H4. Almost two turns of DNA are wrapped around this octameric core, which represses transcription. The histone amino termini extend from the core, where they can be modified post-translationally by acetylation, phosphorylation, ubiquitination, and methylation, affecting their charge and function. Acetylation of the ε-amino groups of specific histone lysines is catalyzed by histone acetyltransferases (HATs) and correlates with an open chromatin structure and gene activation. Histone deacetylases (HDACs) catalyze the hydrolytic removal of acetyl groups from histone lysine residues and correlates with chromatin condensation and transcriptional repression. Therefore, HDAC inhibition results in transcriptional activation through the conformational relaxation of DNA. Changes in the transcription of key genes has linked HDAC inhibitors to blocking angiogenesis and cell cycling, and promoting apoptosis and differentiation. By targetingthese key components of tumor proliferation, HDAC inhibitors are currently being explored as potential anticancer agents.
Usage:
For research use only (RUO)
Storage:
This kit will perform as specified if stored as directed at -80°C and used before the expiration date indicated on the outside of the box.HDAC Assay Buffer (10X) -20°CHDAC1 (human recombinant) -80°CHDAC Trichostatin A -20°CHDAC Substrate -20°C96-Well Plate (Black) Room temperatureHDAC Developer -20°C96-Well Cover Sheet Room temperature
Kit Components:
HDAC Assay Buffer (10X) 1 vialHDAC1 (human recombinant) 1 vialHDAC Trichostatin A 1 vialHDAC Substrate 1 vial96-Well Plate (Black) 1 plateHDAC Developer 2 vials96-Well Cover Sheet 1 cover


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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