Human IDO1 Cell-Based Assay Kit
Cat.No. : | Kit-1754 |
Product Overview : | L-tryptophan (L-Trp) is an essential amino acid necessary for protein synthesis in mammalian cells and the L-Trp to kynurenine (Kyn) pathway is firmly established as a key regulator of innate and adaptive immunity. Catabolism of L-Trp to Kyn maintains an immunosuppressive microenvironment by starving immune cells of L-Trp and releasing degradation products of LTrp that have immunosuppressive functions. Indoleamine 2,3-dioxygenases (IDO1 & IDO2), two of the rate limiting enzymes in this pathway, are upregulated in many tumors, providing cancer cells with an avenue for immune evasion. |
- Specification
- Gene Information
- Related Products
Size : | 100 reactions |
Applications : | Screen for inhibitors of hIDO1 enzyme in a cellular context. Note: The expression vector is designed for use in transient transfection protocols. It is NOT SUITABLE for transformation and amplification in bacteria. |
Storage : | Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival. |
Products Types
◆ Recombinant Protein | ||
IDO1-3829H | Recombinant Human IDO1 protein, GST-tagged | +Inquiry |
IDO1-01H | Recombinant Human IDO1 Protein, His/Avi-tagged | +Inquiry |
Ido1-2126M | Recombinant Mouse Indoleamine 2,3-dioxygenase 1, His-tagged | +Inquiry |
IDO1-2077M | Recombinant Mouse IDO1 Protein (1-407 aa), His-tagged | +Inquiry |
IDO1-1138H | Recombinant Human IDO1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IDO1-5300HCL | Recombinant Human IDO1 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1763 | IDO1 Inhibitor Mechanism of Action Assay Kit | +Inquiry |
Kit-1755 | Human IDO1 Fluorogenic Inhibitor Screening Assay Kit | +Inquiry |
Kit-2211 | Indoleamine 2,3-Dioxygenase 1 Activity Assay Kit | +Inquiry |
Kit-1757 | Human IDO1 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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