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Native Clostridium tetani Tetanus toxin

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Product Overview:
Tetanus toxin from Clostridium tetani has been used to inhibit vesicular release in Pannexin 1-transfected Neuro2A cells1.
Binds to polysialogangliosides acceptors on surface of all peripheral presynaptic nerve terminals. Internalized by receptor-mediated endocytosis and carried to spinal cord and brain by transsynaptic retrograde transport. Blocks the release of glycine from inhibitory interneurons of the spinal cord. Cleaves synaptobrevin (VAMP-2), and blocks synaptic vesicle exocytosis in vivo.
C. tetani
C. tetani
Two bands by SDS-PAGE under reducing conditions (100 kDa heavy chain and 50 kDa light chain).
Molecular Mass:
150 kDa (heavy chain (100 kDa) and a light chain (50 kDa) connected through an interchain disulfide bond)
Each lot of tetanus toxin is tested to confirm binding activity to GT1b ganglioside using the hemagglutination assay of Tayot, et al.
Store at 2-8 centigrade
Each vial, when reconstituted with 100μL of sterile purified water, contains 25μg of tetanus toxin in 20 mM HEPES, pH 7.4 with 1.25% lactose.

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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-097-1828
FAX: 1-631-938-8127

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