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Native Clostridium tetani Tetanus toxin

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Cat.No.:
tetX-110C
Product Overview:
Tetanus toxin from Clostridium tetani has been used to inhibit vesicular release in Pannexin 1-transfected Neuro2A cells1.
Description:
Binds to polysialogangliosides acceptors on surface of all peripheral presynaptic nerve terminals. Internalized by receptor-mediated endocytosis and carried to spinal cord and brain by transsynaptic retrograde transport. Blocks the release of glycine from inhibitory interneurons of the spinal cord. Cleaves synaptobrevin (VAMP-2), and blocks synaptic vesicle exocytosis in vivo.
Source:
C. tetani
Species:
C. tetani
Bio-activity:
Two bands by SDS-PAGE under reducing conditions (100 kDa heavy chain and 50 kDa light chain).
Molecular Mass:
150 kDa (heavy chain (100 kDa) and a light chain (50 kDa) connected through an interchain disulfide bond)
Applications:
Each lot of tetanus toxin is tested to confirm binding activity to GT1b ganglioside using the hemagglutination assay of Tayot, et al.
Storage:
Store at 2-8 centigrade
Reconstitution:
Each vial, when reconstituted with 100μL of sterile purified water, contains 25μg of tetanus toxin in 20 mM HEPES, pH 7.4 with 1.25% lactose.


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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