|Product Overview:||Echistatin α1 isoform was isolated from V. venoms|
|Description:||Disintegrins represent a novel family of integrin β1 and β3 inhibitor proteins isolated from viper venoms. They are low molecular-weight, cysteine-rich peptides containing the Arg-Gly-Asp (RGD) sequence. They are the most potent known inhibitors of integrin function. Disintegrins interfere with cell adhesion to the extracellular matrix, including adhesion of melanoma cells and fibroblasts to fibronectin, and are potent inhibitors of platelet aggregation.|
|Molecular Mass:||5400 kDa|
|Applications:||Echistatin has been used as an inhibitor of integrin function to study the role of microfibril-associated glycoprotein-1 (Magp1) in the morphogenesis of vascular structures. It also been used for the preparation of microbubbles targeted to αvβ3 integrins in tumor angiogenesis imaging and as a conjugate to αvβ3 in flow cytometric binding studies.|
|Storage:||Store at -20 centigrade|
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