Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-097-1828   Email:
Home > Products > Assay Kits > Activity Kits > PAD4 Inhibitor Screening Assay Kit

PAD4 Inhibitor Screening Assay Kit

"PAD4" Related Products.
96 wells
Protein Arginine Deiminase 4 (PAD4) is a guanidino-modifying enzyme that functions as a transcriptional coregulator catalyzing the conversion of specific arginine residues to citrulline. Substrates for PAD4 include histones H2A, H3, and H4. PAD4 autocitrullinates itself at several sites, inhibiting its enzymatic activity. PAD4 activity is increased in rheumatoid arthritis, producing an abundance of citrulline-containing proteins that generate an immune response resulting in production of autoantibodies that ultimately attack the host tissues. PAD4 has also been implicated in several other diseases including multiple sclerosis, Alzheimer"s disease, glaucoma, and cancer. The PAD4 Inhibitor Screening Assay (Ammonia) provides a convenient, fluorescence-based method for screening human PAD4 inhibitors.
Kit Components:
PAD Assay Buffer: 1 vial/30 ml; -20°CPAD4 (human recombinant) Assay Reagent: 2 vials/60 µl; -80°CPAD Substrate: 2 vials/lyophilized; -20°CPAD Stop Solution: 2 vials/1.2 ml; -20°CPAD Ammonia Detector: 2 vials/lyophilized; -20°CEthanol Assay Reagent: 1 vial/2 ml; RT96-Well Solid Plate (black): 1 plate; RT96-Well Cover Sheet: 1 cover; RT

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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-097-1828
FAX: 1-631-938-8127

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