PCSK9-LDLR TR-FRET Assay Kit

• Cat.No.: Kit-1808
• Product Overview: PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to the ectodomain of hepatic low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. PCSK9 acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation

Specification

• Size: 384 reactions
• Applications: Great for screening small molecular inhibitors for drug discovery and HTS applications.
• Storage: At least 6 months from date of receipt when stored as directed.