Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-048-3343   Email: info@creative-biomart.com
Home > Products > Assay Kits > Signaling Kits > Potassium Ion Channel Assay Kit

Potassium Ion Channel Assay Kit

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Cat.No.:
Kit-2042
Product Overview:
The Potassium Ion Channel kit is a no-wash cell based homogenous assay for high throughput screening measurements of potassium channel activity. Using thallium influx as a surrogate indicator of potassium ion channel activity, the assay is based on the activation of a proprietay fluorescent dye with a high affinity for thallium that reports potassium channel activity with a large fluorogenic signal which is propotional to the number of open potassium channels on the cell. The assay can be performed in a convenient 96-well or 384-well microtiter-plate format and easily adapted to automation without a separation step. Its signal can be read by a fluorescence microplate reader at Ex/Em = 488/525 nm (bottom read).
Size:
10 plates
Description:
Potassium channels are a diverse and ubiquitous family of membrane proteins present in most cell types and control a wide variety of cell functions. Potassium (K+) channels play key role in regulating such processes as heart rate, hormone secretion, neurotransmitter release, electrolyte and water balance, and cell division/proliferation. Given their physiological importance, K+ channels have emerged as targets of drug discovery efforts for such indications as diabetes, epilepsy, pain, immunomodulation, arrhythmia, dementia, and others.
Applications:
Potassium channel or transporter activity.
Storage:
Keep Component A at -20°C and avoid exposure to light; Component B at 4°C, and Component C at room temperature. All components are stable for 6 months after receipt if stored properly.
Kit Components:
Component A: Thallium Indicator Dye 1 vial (0.9 mg)Component B: NYPR Solution, Probenecid Substitute 1 bottle (5 ml)Component C: 10x KAB Buffer 1 bottle (10 ml)
Detection method:
FlexStation or Microplate reader


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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