Recombinant Canine VEGFA protein
Cat.No. : | VEGFA-453C |
Product Overview : | Recombinant Canine VEGFA was expressed in Yeast. Canine VEGF-A was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified. |
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Description : | Vascular endothelial growth factor (VEGF) proteins stimulate vasculogenesis and angiogenesis. They are part of the system that restores the oxygen supply to tissues when blood circulation is inadequate. The normal function of VEGF proteins is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels. The VEGF family has six members, including VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and Placental Growth Factor (PGF). Activity of VEGF-A, as its name implies, has been studied mostly on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g., stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells). In vitro, VEGF-A has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF-A is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor (VPF). |
Source : | Yeast |
Species : | Canine |
Molecular Mass : | Has a predicted molecular weight of 22.0 kDa. |
Protein length : | 188 aa |
AA Sequence : | APMAGGEHKP HEVVKFMDVY QRSYCRPIET LVDIFQEYPD EIEYIFKPSC VPLMRCGGCC NDEGLECVPT EEFNITMQIM RIKPHQGQHI GEMSFLQHSK CECRPKKDRA RQEKKSIRGK GKGQKRKRKK SRYKPWSVPC GPCSERRKHL FVQDPQTCKC SCKNTDSRCK ARQLELNERT CRCDKPRR (188) |
Applications : | The Canine VEGF-A protein can be used in cell culture, as an VEGF-A ELISA Standard, and as a Western Blot Control. |
Gene Name : | VEGFA vascular endothelial growth factor A [ Canis lupus familiaris ] |
Official Symbol : | VEGFA |
Synonyms : | VEGF; VEGF-A; VPF; vascular endothelial growth factor 188; vascular permeability factor |
Gene ID : | 403802 |
mRNA Refseq : | NM_001003175 |
Protein Refseq : | NP_001003175 |
UniProt ID : | Q9MYV3 |
Chromosome Location : | chromosome: 12 |
Pathway : | AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; EPH-Ephrin signaling, organism-specific biosystem |
Function : | chemoattractant activity; fibronectin binding; receptor agonist activity |
Products Types
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◆ Lysates | ||
VEGFA-1427HCL | Recombinant Human VEGFA cell lysate | +Inquiry |
VEGFA-974HCL | Recombinant Human VEGFA cell lysate | +Inquiry |
VEGFA-522RCL | Recombinant Rat VEGFA cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionStudies have shown that there is an association between the expression level of VEGFA protein and other biomarkers, for example, it can be associated with indicators such as tumor cell differentiation, metastatic capacity, and prognosis.
At present, a variety of drugs have been developed to target the VEGFA protein and its related signaling pathway, including inhibiting its expression and inhibiting its binding to receptors, etc., for the treatment of tumors and other vascular-related diseases.
VEGFA protein plays a key role in tumor angiogenesis, promoting tumor growth and metastasis by stimulating endothelial cell proliferation, migration, and vascular network formation.
The expression of VEGFA protein in different tissues and organs is different, and it is expressed in tumor tissue, cardiovascular system and other tissues and organs, and the expression level may be affected by many factors.
Studies have shown that the expression level of VEGFA protein is related to the degree of malignancy of the tumor, and the high expression of VEGFA protein often indicates that the tumor is more aggressive.
VEGFA protein plays an important role in cardiovascular disease by regulating endothelial cell function, promoting vascular repair and maintaining cardiovascular system homeostasis.
Customer Reviews (2)
Write a reviewVEGFA's catalytic activity is so strong that it can adapt even in the face of complex chemical reactions.
VEGFA they produced was highly active and the experimental effect was obvious.
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