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Active Recombinant Cynomolgus/Rhesus CTLA4 protein, His-tagged

Cat.No. : CTLA4-354C
Product Overview : Recombinant Cynomolgus/Rhesus CTLA4 protein(XP_005574071.1/Q9BDC4) (Met1-Asp161) was expressed in HEK293, fused with a polyhistidine tag at the C-terminus.
  • Specification
  • Gene Information
  • Related Products
Source : HEK293
Species : Cynomolgus/Rhesus
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : Immobilized cynomolgus/rhesus CTLA4-His at 10 μg/ml (100 μl/well) can bind Cynomolgus CD80-Fc, The EC50 of cynomolgus/rhesus CD80-Fc is 0.02-0.04 μg/ml.
Molecular Mass : The recombinant cynomolgus / rhesus CTLA4 comprises 136 amino acids and has a calculated molecular mass of 14.9 KDa. The apparent molecular mass of it is approximately 24 and 21 KDa respectively in SDS-PAGE due to different glycosylation.
Protein length : Met1-Asp161
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : >95% as determined by SDS-PAGE.
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended to reconstitute the lyophilized powder in sterile water to 100-200 ug/ml, and further dilute with other solvents. The dissolved protein can be stored at 4°C for 2-7 days and should be used up as soon as possible. If not in use for a short time, please store at -20°C.
Gene Name : CTLA4 cytotoxic T-lymphocyte associated protein 4 [ Macaca fascicularis (crab-eating macaque) ]
Official Symbol : CTLA4
Synonyms : CTLA4
Gene ID : 102115124
mRNA Refseq : XM_005574014
Protein Refseq : XP_005574071

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there ongoing clinical trials exploring CTLA-4 inhibitors in combination with other immunotherapies? 05/16/2020

Yes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.

How does the expression of CTLA-4 vary in different types of immune cells? 10/17/2019

CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.

In what ways can CTLA-4 be utilized in organ transplantation? 01/11/2017

Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.

How does CTLA-4 contribute to the maintenance of immune tolerance? 04/30/2016

CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.

How does CTLA-4 blockade differ from PD-1/PD-L1 blockade in cancer immunotherapy? 03/18/2016

While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.

Customer Reviews (3)

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Reviews
04/17/2019

    It has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.

    11/25/2018

      The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.

      01/28/2017

        the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.

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