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Recombinant E. coli acnB protein(Met1-Val865)

Cat.No. : acnB-487E
Product Overview : Recombinant E.Coli (strain K12) acnB (P36683) (Met 1-Val 865) was expressed and purified in E. coli.
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  • Gene Information
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Source : E. coli
Species : E. coli
Tag : N/A
Protein length : Met1-Val865
Form : Lyophilized from sterile 40mM Tris, 1mM DTT, pH 8.2. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant E.Coli acnB consisting of 865 amino acids and has a calculated molecular mass of 93.5 kDa. It migrates as an approximately 95 kDa band in SDS-PAGE under reducing conditions.
Purity : > 97 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Why is acnB a potential target for new antimicrobial drugs? 12/09/2022

 AcnB is a critical component of bacterial metabolism and physiology, making it an attractive target for the development of new antimicrobial drugs. Inhibiting its function could interfere with bacterial growth and survival.

Are there any existing drugs that target acnB? 07/25/2022

Currently, there are no drugs that specifically target acnB. However, some antimicrobial drugs, such as pyruvate dehydrogenase inhibitors, indirectly affect the function of acnB by disrupting the TCA cycle.

What is the function of ACNB? 03/29/2021

AcnB is responsible for the conversion of aconitate to isocitrate in the TCA cycle. This is a crucial step that produces energy in the form of ATP, NADH, and FADH2.

What other functions does acnB have in bacterial physiology besides its role in the TCA cycle? 02/14/2021

AcnB has been found to be involved in the regulation of gene expression in response to changes in oxygen levels and in the regulation of cellular iron levels.

Why is acnB important for bacterial growth and survival?  08/06/2019

AcnB is important for bacterial growth and survival because it plays a critical role in the metabolism and physiology of bacteria. It is essential for producing energy and regulating cellular processes.

What are some challenges in developing drugs that target acnB? 07/30/2017

One challenge in developing drugs that target acnB is finding compounds that specifically inhibit its activity without affecting other essential enzymes in the TCA cycle. Another challenge is developing drugs that can penetrate bacterial cell walls and reach their target inside the cell. In addition, the potential for bacterial resistance to emerge against acnB inhibitors must be considered in drug development.

What structural features does acnB have that make it a potential target for drug development?  04/10/2017

 AcnB has a distinct active site with unique structural features that distinguish it from other enzymes in the TCA cycle. These features make it a potential target for developing selective inhibitors that could interfere with bacterial metabolism and growth without affecting human cells.

How has the study of acnB contributed to our understanding of bacterial metabolism and physiology?  02/13/2015

The study of acnB has contributed significantly to our understanding of bacterial metabolism and physiology. It has provided insights into the critical role of the TCA cycle in energy production and regulation of cellular processes. It has also uncovered the regulatory mechanisms of gene expression and cellular iron homeostasis. These findings have implications for developing new treatments for bacterial infections and understanding the evolution of microbial pathogens.

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