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Recombinant HIV HIV2gp36 protein, His-tagged

Cat.No. : HIV2gp36-200H
Product Overview : Recombinant HIV-2 gp36 produced in E.coli is a non-glycosylated polypeptide chain having a molecular mass of 17kDa and fused to a His tag at N-terminus.
  • Specification
  • Gene Information
  • Related Products
Description : HIV-1 and HIV-2 appear to package their RNA differently. HIV-1 binds to any appropriate RNA whereas HIV-2 preferentially binds to mRNA which creates the Gag protein itself. This means that HIV-1 is better able to mutate. HIV-2 is transmitted in the same ways as HIV-1: Through exposure to bodily fluids such as blood, semen, tears and vaginal fluids. Immunodeficiency develops more slowly with HIV-2. HIV-2 is less infectious in the early stages of the virus than with HIV-1. The infectiousness of HIV-2 increases as the virus progresses. Major differences include reduced pathogenicity of HIV-2 relative to HIV-1, enhanced immune control of HIV-2 infection and often some degree of CD4-independence. Despite considerable sequence and phenotypic differences between HIV-1 and 2 envelopes, structurally they are quite similar. Both membrane-anchored proteins eventually form the 6-helix bundles from the N-terminal and C-terminal regions of the ectodomain, which is common to many viral and cellular fusion proteins and which seems to drive fusion. HIV-1 gp41 helical regions can form more stable 6-helix bundles than HIV-2 gp41 helical regions however HIV-2 fusion occurs at a lower threshold temperature (25°C), does not require Ca2+ in the medium, is insensitive to treatment of target cells with cytochalasin B, and is not affected by target membrane glycosphingolipid composition.
Source : E. coli
Species : HIV
Tag : His
Form : Sterile Filtered White lyophilized (freeze-dried) powder. Lyophilized from 1mg/ml in 1xPBS, pH 7.4 and 0.3% SDS.
Molecular Mass : 17kDa
Purity : Greater than 95.0% as determined by SDS-PAGE.
Usage : The products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Stability : HIV-2 gp36 although stable at room temperature for 4 weeks, should be stored below -18°C. Please prevent freeze thaw cycles.
Solubility : It is recommended to reconstitute the lyophilized HIV-2 gp36 in sterile 18M-cmH2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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