Recombinant Human ADAM15 Protein, GST-tagged

• Cat.No.: ADAM15-276H
• Product Overview: Human ADAM15 full-length ORF ( NP_997074.1, 1 a.a. - 772 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 110.1 kDa
• AA Sequence: MRLALLWALGLLGAGSPLPSWPLPN IGGTEEQQAESEKAPREPLEPQVLQ DDLPISLKKVLQTSLPEPLRIKLEL DGDSHILELLQNRELVPGRPTLVWY QPDGTRVVSEGHTLENCCYQGRVRG YAGSWVSICTCSGLRGLVVLTPERS YTLEQGPGDLQGPPIISRIQDLHLP GHTCALSWRESVHTQKPPEHPLGQR HIRRRRDVVTETKTVELVIVADHSE AQKYRDFQHLLNRTLEVALLLDTFF RPLNVRVALVGLEAWTQRDLVEISP NPAVTLENFLHWRRAHLLPRLPHDS AQLVTGTSFSGPTVGMAIQNSICSP DFSGGVNMDHSTSILGVASSIAHEL GHSLGLDHDLPGNSCPCPGPAPAKT CIMEASTDFLPGLNFSNCSRRALEK ALLDGMGSCLFERLPSLPPMAAFCG NMFVEPGEQCDCGFLDDCVDPCCDS LTCQLRPGAQCASDGPCCQNCQLRP SGWQCRPTRGDCDLPEFCPGDSSQC PPDVSLGDGEPCAGGQAVCMHGRCA SYAQQCQSLWGPGAQPAAPLCLQTA NTRGNAFGSCGRNPSGSYVSCTPRD AICGQLQCQTGRTQPLLGSIRDLLW ETIDVNGTELNCSWVHLDLGSDVAQ PLLTLPGTACGPGLVCIDHRCQRVD LLGAQECRSKCHGHGVCDSNRHCYC EEGWAPPDCTTQLKATSSLTTGLLL SLLVLLVLVMLGASYWYRARLHQRL CQLKGPTCQYSLRGQPSPHPQGSHC LPTPRAGAHRVTCPAQGLESRP
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ADAM15 ADAM metallopeptidase domain 15 [ Homo sapiens ]
• Official Symbol: ADAM15
• Synonyms: ADAM15; ADAM metallopeptidase domain 15; a disintegrin and metalloproteinase domain 15 (metargidin); disintegrin and metalloproteinase domain-containing protein 15; MDC15; metargidin; MDC-15; ADAM 15; metalloprotease RGD disintegrin protein; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
• Gene ID: 8751
• mRNA Refseq: NM_003815
• Protein Refseq: NP_003806
• MIM: 605548
• UniProt ID: Q13444