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Recombinant Human ADAMTS18 protein, GST-tagged

Cat.No. : ADAMTS18-26H
Product Overview : Recombinant Human ADAMTS18(892 - 1060 aa) fused with GST tag was expressed in E. coli.
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Description : This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may regulate hemostatic balance and function as a tumor suppressor. Mutations in this gene may be associated with microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT) and cone-rod dystrophy in human patients.
Source : E. coli
Species : Human
Tag : GST
Form : The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization.
AA Sequence : GYINVKAICLRDQNTQVNSSFCSAK TKPVTEPKICNAFSCPAYWMPGEWS TCSKACAGGQQSRKIQCVQKKPFQK EEAVLHSLCPVSTPTQVQACNSHAC PPQWSLGPWSQCSKTCGRGVRKREL LCKGSAAETLPESQCTSLPRPELQE GCVLGRCPKNSRLQWVASS
Purity : 75%, by SDS-PAGE with Coomassie Brilliant Blue staining.
Storage : Stability and Storage:
Store for up to 12 months at -20 centigrade to -80 centigrade as lyophilized powder.
Storage of Reconstituted Protein:
Short-term storage: Store at 2-8 centigrade for two weeks.
Long-term storage: Aliquot and store at -20 centigrade to -80 centigrade for up to 6 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
Reconstitution : Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage (see Stability and Storage for more details).
If a different concentration is needed for your purposes please adjust the reconstitution volume as required (please note: the ion concentration of the final solution will vary according to the volume used).
Note: Centrifuge vial before opening. When reconstituting, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution.
Gene Name : ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 [ Homo sapiens ]
Official Symbol : ADAMTS18
Synonyms : ADAMTS18; ADAM metallopeptidase with thrombospondin type 1 motif, 18; a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 , ADAMTS21; A disintegrin and metalloproteinase with thrombospondin motifs 18; disintegrin and metalloprotease-like protein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21; KNO2; ADAMTS21;
Gene ID : 170692
mRNA Refseq : NM_199355
Protein Refseq : NP_955387
MIM : 607512
UniProt ID : Q8TE60
Chromosome Location : 16q23
Function : metal ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (8)

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Do you provide technical guidance on the use of recombinant proteins? 09/12/2022

We will provide customers with relevant technical support.

Can the Tag and tag location of human ADAMTS18 be customized according to my requirements? 09/21/2021

Yes, we will provide custom-manufactured recombinant proteins according to your requirements.

What is the structure domain of ADAMTS18? 08/22/2021

The structure of ADAMTS18 includes a signal peptide, a prodomain, a metalloproteinase domain, a disintegrin-like domain, a TSP1, a cysrich domain, a spacer and a TSP1-like repeat.

Is ADAMTS18 widely used in disease research? 08/14/2021

ADAMTS18 has been more frequently studied in esophageal cancer, osteosarcoma and endometrial cancer.

In which tissues is ADAMTS18 abundantly expressed? 04/14/2021

ADAMTS18 is mainly expressed in adult brain, prostate and retina tissues.

How do you purify the protein? 10/25/2020

We have adopted multiple purification methods, including hydrophobic chromatography, affinity chromatography, ion exchange chromatography, salting out, molecular sieve, etc.

What is the biological function of ADAMTS18? 06/18/2020

Expression of ADAMTS18 reduced cancer cell replication and growth, suggesting that it has a tumor-suppressive effect.

Where is the cellular localization of ADAMTS18? 06/18/2020

ADAMTS18 is mainly localized in the cytoplasm.

Customer Reviews (4)

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Reviews
11/19/2022

    The delivery was fast, which solved my urgent needs.

    05/09/2021

      The ADAMTS18 proteins purchased from your company is suitable for ELISA.

      05/05/2021

        Purchased the right product at the right price and with the best quality.

        08/13/2020

          The technicians understand the customer's experimental needs and have helped me to solve many of the problems that have arisen during the experiments.

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