Recombinant Human AFF1 Protein, GST-tagged
Cat.No. : | AFF1-405H |
Product Overview : | Human AFF1 partial ORF ( NP_005926.1, 71 a.a. - 170 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 36.74 kDa |
AA Sequence : | LSTKSHTHRLDASENRLGKPKYPLI PDKGSSIPSSSFHTSVHHQSIHTPA SGPLSVGNISHNPKMAQPRTEPMPS LHAKSCGPPDSQHLTQDRLGQEGFG |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AFF1 AF4/FMR2 family, member 1 [ Homo sapiens ] |
Official Symbol : | AFF1 |
Synonyms : | AFF1; AF4/FMR2 family, member 1; MLLT2, myeloid/lymphoid or mixed lineage leukemia (trithorax (Drosophila) homolog); translocated to, 2, PBM1, pre B cell monocytic leukemia partner 1; AF4/FMR2 family member 1; AF 4; AF4; protein AF-4; proto-oncogene AF4; pre-B-cell monocytic leukemia partner 1; ALL1-fused gene from chromosome 4 protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2; PBM1; MLLT2; MGC134969; |
Gene ID : | 4299 |
mRNA Refseq : | NM_001166693 |
Protein Refseq : | NP_001160165 |
MIM : | 159557 |
UniProt ID : | P51825 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAFF1 protein holds potential as a target for modulating gene expression or disease phenotypes, and further research is needed to explore its implications for therapeutic interventions.
Genetic variations or mutations in the gene encoding AFF1 protein may impact its expression or function, influencing cellular processes or disease susceptibility.
AFF1 protein contributes to cellular processes such as development, differentiation, or disease progression, and the underlying molecular mechanisms are currently being investigated.
Various experimental techniques or assays, such as chromatin immunoprecipitation, RNA-seq, or gene knockdown approaches, have been used to study the functional significance of AFF1 protein.
Post-translational modifications and regulatory mechanisms may modulate the activity or stability of AFF1 protein.
Dysregulation or dysfunction of AFF1 protein can affect transcriptional regulation, perturb gene expression networks, and contribute to disease development.
The expression of AFF1 protein is regulated by specific factors and signaling pathways.
AFF1 protein plays a role in gene transcription or chromatin remodeling, and its function can be investigated using techniques like chromatin immunoprecipitation or gene expression analysis.
The subcellular localization of AFF1 protein can be experimentally determined using techniques such as immunofluorescence microscopy or subcellular fractionation.
AFF1 protein may interact with specific molecules or participate in protein complexes, which have functional implications in cellular processes.
Customer Reviews (3)
Write a reviewInvestigating protein-protein interactions in cellular senescence for aging-related diseases.
Mapping protein-protein interactions in immune checkpoint regulation for immunotherapy.
Unraveling protein-protein interactions in RNA splicing for gene expression regulation.
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