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Recombinant Human AGER Protein, His-Flag-StrepII-tagged

Cat.No. : AGER-421P
Product Overview : Purified AGER (AAH20669.1 23 a.a. - 342 a.a.) human recombinant protein with His-Flag-StrepII tag at N-terminus expressed in human cells.
  • Specification
  • Gene Information
  • Related Products
Description : The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
Source : HEK293
Species : Human
Tag : His-Flag-StrepII
Form : Liquid
Bio-activity : Not Tested
Molecular Mass : 40.48 kDa
AA Sequence : AQNITARIGEPLVLKCKGAPKKPPQ RLEWNLNTGRTEAWKVLSPQGGGPW DSVARVLPNGSLFLPAVGIQDEGIF RCQAMNRNGKETKSNYRVRVYQIPG KPEIVDSASELTAGVPNKVGTCVSE GSYPAGTLSWHLDGKPLVPNEKGVS VKEQTRRHPETGLFTLQSELMVTPA RGGDPRPTFSCSFSPGLPRHRALRT APIQPRVWEPVPLEEVQLVVEPEGG AVAPGGTVTLTCEVPAQPSPQIHWM KDGVPLPLPPSPVLILPEIGPQDQG TYSCVATHSSHGPQESRAVSISIIE PGEEGPTAGSVGGSGLGTLA
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Storage : Store at -80centigrade. Aliquot to avoid repeated freezing and thawing.
Concentration : ≥ 10 ug/ml
Storage Buffer : 100 mM Tris-HCl pH 8.0, 150 mM NaCl, 1 mM EDTA, and 5 mM desthiobiotin.
Gene Name : AGER advanced glycosylation end product-specific receptor [ Homo sapiens ]
Official Symbol : AGER
Synonyms : AGER; advanced glycosylation end product-specific receptor; RAGE; RAGE isoform sRAGE-delta; RAGE isoform NtRAGE-delta;
Gene ID : 177
mRNA Refseq : NM_001136
Protein Refseq : NP_001127
MIM : 600214
UniProt ID : Q15109

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (20)

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How does AGER affect bone health? 09/02/2022

AGER is involved in bone metabolism and might influence osteoporosis and bone diseases.

Are there diagnostic applications for AGER? 08/10/2022

AGER levels might serve as biomarkers for certain diseases, including diabetes.

How does AGER interact with AGEs? 07/05/2022

AGER binds AGEs, initiating signaling cascades linked to inflammation, oxidative stress, and tissue damage.

How is AGER implicated in skin aging? 05/30/2022

AGER contributes to skin aging through oxidative stress and collagen damage.

What is the AGER protein? 07/15/2021

AGER stands for "Advanced Glycosylation End-Product Specific Receptor," a cell surface receptor.

Can the AGER protein impact inflammation? 07/15/2021

Yes, AGER activation contributes to inflammation and immune responses.

How does AGER impact wound healing? 02/05/2021

AGER activation can impair wound healing through inflammation and oxidative stress.

How does AGER influence neurodegenerative diseases? 01/22/2021

AGER contributes to neuroinflammation and might play a role in neurodegeneration.

Can AGER influence kidney function? 12/06/2020

AGER contributes to diabetic nephropathy and kidney dysfunction.

How does the AGER protein interact with AGEs? 09/23/2020

AGER binds to AGEs, initiating cellular signaling pathways linked to inflammation and oxidative stress.

Can AGER influence lung health? 01/31/2020

AGER is implicated in lung diseases and inflammation, such as chronic obstructive pulmonary disease.

Are there therapeutic strategies targeting AGER? 06/09/2019

Researchers explore compounds that modulate AGER to mitigate its effects.

How is AGER involved in diabetic complications? 05/13/2019

AGER contributes to diabetic complications by promoting inflammation and tissue damage.

How is the AGER protein involved in research? 01/28/2019

AGER is studied for its implications in aging, diabetes, and various age-related diseases.

What is the function of the AGER protein? 07/25/2018

AGER plays a role in mediating cellular responses to advanced glycation end products (AGEs).

Are there dietary interventions for AGER-related effects? 10/05/2017

Consuming a low-AGE diet may help reduce AGER activation and its negative effects.

Can AGER impact immune responses? 06/29/2017

AGER activation affects immune cell functions and influences immune responses.

Does AGER affect cardiovascular health? 12/04/2016

AGER activation is linked to cardiovascular diseases, including atherosclerosis.

Are there other ligands for the AGER protein? 11/25/2016

Yes, besides AGEs, AGER interacts with other ligands like HMGB1 and β-amyloid.

Is AGER research ongoing? 11/02/2016

Yes, ongoing research aims to uncover new roles and therapeutic targets related to AGER.

Customer Reviews (5)

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Reviews
02/26/2022

    It's quality was evident in consistent results across replicates.

    08/13/2021

       Protein consistently upregulated the expression of tissue-specific markers.

      01/20/2020

         Gel electrophoresis bands displayed distinct separation, showcasing the product’s purity.

        06/22/2019

          It’s consistent outcomes supported reliable statistical analysis.

          01/11/2017

            Consistency and Compatibility Consistency in the product’s performance bolstered the credibility of our research findings.

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