Recombinant Human AMH protein, His-tagged
Cat.No. : | AMH-892H |
Product Overview : | Recombinant Human AMH (NP_000470.2) (Leu25-Arg560) fused with His tag was produced in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from sterile 20 mM Tris, 150 mM NaCl, pH 8.0. |
Molecular Mass : | The recombinant human AMH consists of 555 amino acids and predicts a molecular mass of 59.1 kDa. As a result of proteolytic cleavage, it migrates as three bands (63.6, 40.5, 35 kDa) corresponding to the full length and the cleaved two polypeptides respectively in SDS-PAGE under reducing conditions. |
Protein Length : | Leu25-Arg560 |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 90 % as determined by SDS-PAGE. |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | AMH anti-Mullerian hormone [ Homo sapiens ] |
Official Symbol : | AMH |
Synonyms : | AMH; anti-Mullerian hormone; muellerian-inhibiting factor; MIS; anti-Muellerian hormone; Mullerian inhibiting factor; Mullerian inhibiting substance; muellerian-inhibiting substance; MIF; |
Gene ID : | 268 |
mRNA Refseq : | NM_000479 |
Protein Refseq : | NP_000470 |
MIM : | 600957 |
UniProt ID : | P03971 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMH interacts with hormones like FSH and estrogen to modulate the balance between follicular development and follicle selection.
AMH expression is influenced by genetic variations and epigenetic modifications that can contribute to inter-individual differences in AMH levels.
AMH inhibits the development of M眉llerian ducts in males, promoting the differentiation of Sertoli cells and the formation of the male reproductive system.
Deficiency or overexpression of AMH can lead to reproductive abnormalities, such as altered fertility, impaired gonadal development, or disorders of sexual differentiation.
In females, AMH plays a role in regulating the regression of M眉llerian ducts and inhibiting follicular development.
Modulating AMH signaling pathways may hold therapeutic potential for infertility treatments and the management of reproductive disorders by manipulating follicular development or regulating reproductive organ development.
Dysregulation of AMH has been associated with reproductive disorders, including polycystic ovary syndrome (PCOS) characterized by increased AMH levels, and disorders of sexual development (DSD) associated with AMH deficiency or insensitivity.
AMH levels can serve as a valuable biomarker for assessing ovarian reserve and predicting ovarian response to fertility treatments like in vitro fertilization (IVF).
AMH expression is tightly regulated during gonadal development and sex determination, primarily controlled by the transcription factors involved in testis development, such as SRY (Sex-determining Region Y) protein.
AMH activates the transforming growth factor-beta (TGF-尾) signaling pathway, which plays a crucial role in regulating reproductive organ development and functions.
Customer Reviews (3)
Write a reviewReduced assay optimization time for faster results.
High-throughput compatibility for efficient data acquisition.
Stable reagents for long-term assay reproducibility.
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