Recombinant Human ARNT protein, GST-tagged

• Cat.No.: ARNT-288H
• Product Overview: Recombinant Human ARNT fused with GST tag at N-terminal was expressed in Insect cells.

Specification

• Description: The transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT), alternatively named Hypoxia-inducible factor (HIF)-1β, is part of the Hypoxia-inducible factor (HIF) pathway which mediates cellular adaptations to hypoxia and promotes tumour progression. Unlike HIF-1α that is regulated in an oxygen-dependent manner, HIF-1β is constitutively expressed. It has been shown that some tumour cells are capable to elevate HIF-1β in response to hypoxia to for a clonal advantage. HIF-1β binds HIF-1α, and forms the transcriptional active HIF-1 complex in the nucleus.
• Source: Insect cells
• Species: Human
• Tag: GST
• Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: 120 kDa
• Purity: > 70%
• Applications: Western Blot
• Stability: 1 year at -70 centigrade from the date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: ARNT aryl hydrocarbon receptor nuclear translocator [ Homo sapiens ]
• Official Symbol: ARNT
• Synonyms: ARNT; aryl hydrocarbon receptor nuclear translocator; bHLHe2; HIF 1beta; dioxin receptor, nuclear translocator; class E basic helix-loop-helix protein 2; hypoxia-inducible factor 1, beta subunit; HIF1B; TANGO; HIF1BETA; HIF-1beta; HIF1-beta; HIF-1-beta
• Gene ID: 405
• mRNA Refseq: NM_001668
• Protein Refseq: NP_001659
• MIM: 126110
• UniProt ID: P27540
• Chromosome Location: 1q21
• Pathway: Angiogenesis, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, organism-specific biosystem; Notch-mediated HES/HEY network, organism-specific biosystem; Pathways in cancer, organism-specific biosystem; Renal cell carcinoma, organism-specific biosystem
• Function: aryl hydrocarbon receptor activity; aryl hydrocarbon receptor binding; protein binding; protein heterodimerization activity; contributes_to sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; contributes_to sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; signal transducer activity; transcription coactivator activity; transcription factor binding