"ATIC" Related Products

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Recombinant Human ATIC protein, His-tagged

Cat.No.: ATIC-24H
Product Overview: Recombinant Human ATIC, fused with N-His tag, was expressed in E. coli.
Description: Bifunctional purine biosynthesis protein PURH is a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity.A mutation in this gene results in AICA-ribosiduria.
Source: E.coli
Species: Human
Tag: His
Form: 20mM Tris.Cl, 50mM NaCl, 50% Glycerol, pH8.0.
Molecular Mass: 66.5kDa(including fusion tag)
Protein length: 607aa(including fusion tag)
Applications: WB, ELISA, IP, antibody production, protein array
Storage: Store at -80°C and avoid repeated freeze-thaw cycles.
Gene Name: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [ Homo sapiens ]
Official Symbol: ATIC
Synonyms: ATIC; AICARFT; IMPCHASE; PURH; AICAR; FLJ93545;
Gene ID: 471
mRNA Refseq: NM_004044
Protein Refseq: NP_004035
MIM: 601731
UniProt ID: P31939
Chromosome Location: Inosine monophosphate biosynthesis, PRPP + glutamine =>IMP, organism-specific biosystem; Inosine monophosphate biosynthesis, PRPP + glutamine => IMP, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem;
Pathway: IMP cyclohydrolase activity; hydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity; protein homodimerization activity; transferase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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