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Recombinant Human BMP4 protein

Cat.No. : BMP4-261H
Product Overview : Recombinant Human BMP4, transcript variant 1, was expressed in HeLa.
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  • Gene Information
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Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers.
Source : HeLa
Species : Human
Form : Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer, 100mM NaCl, pH 7.2
Molecular Mass : 46.4
AA Sequence : HHSQRARKKNKNCRRHSLYVDFSDV GWNDWIVAPPGYQAFYCHGDCPFPL ADHLNSTNHAIVQTLVNSVNSSIPK ACCVPTELSAISMLYLDEYDKVVLK NYQEMVVEGCGCR
Purity : >95% as determined by SDS-PAGE and Coomassie blue staining
Concentration : Resuspend the protein in the desired concentration in proper buffer
Gene Name : BMP4 bone morphogenetic protein 4 [ Homo sapiens ]
Official Symbol : BMP4
Synonyms : BMP4; bone morphogenetic protein 4; BMP2B; BMP-4; BMP-2B; bone morphogenetic protein 2B; ZYME; OFC11; BMP2B1; MCOPS6;
Gene ID : 652
mRNA Refseq : NM_001202
Protein Refseq : NP_001193
MIM : 112262
UniProt ID : P12644

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is BMP4 applied in spinal fusion surgery? 03/30/2022

BMP4 can be used in spinal fusion surgery to stimulate bone growth and fuse vertebrae together, which can alleviate back pain and stabilize the spine.

Are there any genetic disorders related to BMP4? 07/03/2020

Mutations in BMP4 or its receptors can lead to congenital disorders, such as orofacial clefts and heart defects.

Are there ongoing clinical trials involving BMP4 in regenerative medicine? 07/12/2019

Yes, there are ongoing trials exploring the use of BMP4 in regenerative medicine for conditions like osteoarthritis and tendon injuries.

Are there any potential risks or side effects associated with the clinical use of BMP4? 06/11/2018

Yes, some risks include excessive bone growth, swelling, and inflammation at the application site. These complications can be carefully managed by healthcare providers.

Can BMP4 be used in cosmetic surgery? 02/10/2017

Yes, BMP4 can be used to aid in tissue regeneration in cosmetic procedures, such as in the reconstruction of facial bone defects or enhancement of soft tissue volume.

Customer Reviews (3)

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Reviews
11/22/2020

    The BMP4 protein is a valuable resource for researchers due to its high quality and its ability to meet specific experimental needs.

    08/26/2020

      the manufacturer's technical support team can offer prompt assistance in case any issues arise during the handling or application of the BMP4 protein.

      06/05/2018

        The manufacturer's support can play a crucial role in assisting researchers throughout their trials.

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