Recombinant Human CACNA2D1 protein, Trx-His-SUMO-tagged

• Cat.No.: CACNA2D1-29H
• Product Overview: Recombinant Human CACNA2D1, fused with Trx-His-SUMO tag, was expressed in E. coli.

Specification

• Description: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of acomplex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
• Source: E.coli
• Species: Human
• Tag: Trx-His-SUMO
• Form: 20mM Hepes, 50mM NaCl, 1‰ Tween20, pH8.0.
• Molecular Mass: 148kDa(including fusion tag)
• Protein length: 1315aa(including fusion tag)
• Applications: WB, ELISA, IP, antibody production, protein array
• Storage: Store at -80°C and avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 [ Homo sapiens ]
• Official Symbol: CACNA2D1
• Synonyms: CACNA2D1; CACNA2; CCHL2A; CACNL2A
• Gene ID: 781
• mRNA Refseq: NM_000722
• Protein Refseq: NP_000713
• MIM: 114204
• UniProt ID: P54289
• Chromosome Location: Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem
• Pathway: metal ion binding; contributes_to voltage-gated calcium channel activity; voltage-gated ion channel activity