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Recombinant Human CD70 protein, His-tagged

Cat.No. : CD70-56H
Product Overview : Recombinant human CD70, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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Description : CD70, also known as CD70 antigen, is a transmembrane protein in the TNF receptor superfamily. It functions as a co-stimulatory molecule that supports lymphocyte activation and survival. This protein binds to the transmembrane glycoprotein CD27 ligand/CD70 which is expressed on activated B cells, activated T cells, and dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T cell activation, and thus is proliferation of co-stimulated T cells, as well as the generation of cytolytic T cells.
Source : Insect cells
Species : Human
Tag : His tag
Form : Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
Molecular Mass : 18.2kDa (164aa)
AA Sequence : ADPQRFAQAQ QQLPLESLGW DVAELQLNHT GPQQDPRLYW QGGPALGRSF LHGPELDKGQ LRIHRDGIYM VHIQVTLAIC SSTTASRHHP TTLAVGICSP ASRSISLLRL SFHQGCTIAS QRLTPLARGD TLCTNLTGTL LPSRNTDETF FGVQWVRPHH HHHH
Endotoxin : < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity : >90% by SDS - PAGE
Storage : Can be stored at +4centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20Centigrade or -70Centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.25mg/ml (determined by Absorbance at 280nm)
Gene Name : CD70 CD70 molecule [ Homo sapiens ]
Official Symbol : CD70
Synonyms : CD70; CD70 molecule; CD70 antigen; CD27L; CD27-L; CD27LG; TNFSF7
Gene ID : 970
mRNA Refseq : NM_001252
Protein Refseq : NP_001243
MIM : 602840
UniProt ID : P32970
Chromosome Location : 19p13
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : cytokine activity; protease binding; protein binding; receptor binding; tumor necrosis factor receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are some potential CD70-targeted therapies for cancer? 04/29/2023

Antibodies, antibody-drug conjugates, and chimeric antigen receptor (CAR) T-cell therapies are being developed to target CD70 in cancer.

How can CD70-targeted therapies improve cancer treatment outcomes? 05/03/2022

CD70-targeted therapies can enhance the body's immune response against cancer cells and potentially lead to more effective treatments.

In which hematological malignancies is CD70 expression frequently observed? 04/08/2021

CD70 expression is often observed in Hodgkin's lymphoma and certain types of T-cell lymphomas.

Are there any challenges in developing CD70-targeted therapies for cancer? 03/14/2020

Challenges include potential toxicities and finding the right balance to target CD70 effectively without harming normal immune functions.

Are there clinical trials involving CD70-targeted therapies for cancer treatment? 11/14/2018

Yes, there are ongoing clinical trials exploring CD70-targeted therapies for various cancer types.

Customer Reviews (3)

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05/31/2021

    Their collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.

    04/23/2019

      the manufacturer's support is crucial for researchers using CD70 protein in trials.

      03/07/2017

        These resources can enhance the efficiency and accuracy of experimental workflows and contribute to successful outcomes.

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