Recombinant Human CLCA1 protein, His-tagged

• Cat.No.: CLCA1-01H
• Product Overview: Recombinant Human CLCA1(a.a. 22-695) fused with His tag was expressed in E. coli.

Specification

• Description: This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.
• Source: E. coli
• Species: Human
• Tag: His
• Form: PBS buffer (pH 7.4).
• AA Sequence: NSLIQLNNNGYEGIVVAIDPNVPED ETLIQQIKDMVTQASLYLFEATGKR FYFKNVAILIPETWKTKADYVRPKL ETYKNADVLVAESTPPGNDEPYTEQ MGNCGEKGERIHLTPDFIAGKKLAE YGPQGRAFVHEWAHLRWGVFDEYNN DEKFYLSNGRIQAVRCSAGITGTNV VKKCQGGSCYTKRCTFNKVTGLYEK GCEFVLQSRQTEKASIMFAQHVDSI VEFCTEQNHNKEAPNKQNQKCNLRS TWEVIRDSEDFKKTTPMTTQPPNPT FSLLQIGQRIVCLVLDKSGSMATGN RLNRLNQAGQLFLLQTVELGSWVGM VTFDSAAHVQNELIQINSGSDRDTL AKRLPAAASGGTSICSGLRSAFTVI RKKYPTDGSEIVLLTDGEDNTISGC FNEVKQSGAIIHTVALGPSAAQELE ELSKMTGGLQTYASDQVQNNGLIDA FGALSSGNGAVSQRSIQLESKGLTL QNSQWMNGTVIVDSTVGKDTLFLIT WTMQPPQILLWDPSGQKQGGFVVDK NTKMAYLQIPGIAKVGTWKYSLQAS SQTLTLTVTSRASNATLPPITVTSK TNKDTSKFPSPLVVYANIRQGASPI LRASVTALIESVNGKTVTLELLDNG AGADATKDDGVYSRYFTTYDTNGRY SVKVRALGGVNAARRRVIPQQSG
• Purity: > 95% determined by SDS-PAGE.
• Storage: For short term, storage it at +4 centigrade, For long term storage, prepare aliquots with 20% glycerol and store at -20 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.31 mg/ml

Gene Information

• Gene Name: CLCA1 chloride channel accessory 1 [ Homo sapiens ]
• Official Symbol: CLCA1
• Synonyms: CLCA1; chloride channel accessory 1; chloride channel regulator 1 , chloride channel, calcium activated, family member 1; calcium-activated chloride channel regulator 1; CaCC; CLCRG1; chloride channel regulator 1; calcium-dependent chloride channel-1; calcium-activated chloride channel protein 1; CLCA family member 1, chloride channel regulator; calcium-activated chloride channel family member 1; chloride channel, calcium activated, family member 1; CACC; GOB5; CACC1; CaCC-1; hCLCA1; hCaCC-1; FLJ95147
• Gene ID: 1179
• mRNA Refseq: NM_001285
• Protein Refseq: NP_001276
• MIM: 603906
• UniProt ID: A8K7I4
• Chromosome Location: 1p22.3
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Olfactory transduction, organism-specific biosystem; Olfactory transduction, conserved biosystem; Pancreatic secretion, organism-specific biosystem; Pancreatic secretion, conserved biosystem
• Function: chloride channel activity