Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-048-3343   Email: info@creative-biomart.com
Home > Products > Recombinant Proteins > Recombinant Human CMPK1 protein

Recombinant Human CMPK1 protein

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Cat.No.:
CMPK1-46H
Product Overview:
Recombinant Human CMPK1 was expressed in E. coli.
Description:
UMP-CMP kinase plays a critical role in supplying cells with nucleotides by catalysing the phosphorylation of CMP, UMP and dCMP to their respective diphosphates. CMK plays also an important role in the activation of cytidine analogues, aracytidine and gemcitabine, a mainstay of leukaemia and lymphoma therapy. CMK has a remarkable ability of to phosphorylate L-nucleotides from their monophosphate to diphosphate forms as shown for β-L-2’3’-dideoxy-3’thiacytidine (L-SSdC, 3-TC or lamividune), an anti-HIV and anti-hepatitis B drug.
Source:
E. coli
Species:
Human
Form:
150mM KCl, 50mM Tris-Hcl, pH7,5, 2mM β-mercaptoethanol, 50% glycerol.
Bio-activity:
≥1 unit/mg protein.
Molecular Mass:
27kDa
Protein length:
228aa
Unit Definition:
One unit of UMP-CMP kinase converts 1.0 µmole of UMP and ATP to UDP and ADP per minute at pH 7.6 at 25 centigrade, using a coupled enzyme system with PK/LDH.
Applications:
CMK enzyme is a highly pure and active cloned human UMP-CMP Kinase which can be used:• to characterize a monophosphorylated nucleotide analogue as a potential substrate of CMK• to quantify UMP, CMP, dUMP or dCMP in a sample• to synthesize enzymatically the di-phosphate form of nucleotide analogue from its monophosphate form (e.g. dFdC-DP)
Storage:
Store at–20 centigrade


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Optional requirements on this protein +Expand
C-fusion   N-fusion  Non-tagged
His   GST  Fc  Others
<1.0 eu/μg   <0.1 eu/μg  <0.01 eu/μg  Not required
Monomer Isolation   Dimer Isolation   Not required
>80% by SDS-PAGE   >90% by SDS-PAGE  >95% by SDS-PAGE  Others
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45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-048-3343
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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