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Recombinant Human COL3A1 protein, MYC/DDK-tagged

Cat.No. : COL3A1-73H
Product Overview : Recombinant Human COL3A1 fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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  • Gene Information
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Description : This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 135.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : COL3A1 collagen, type III, alpha 1 [ Homo sapiens ]
Official Symbol : COL3A1
Synonyms : COL3A1; collagen, type III, alpha 1; EDS4A, Ehlers Danlos syndrome type IV, autosomal dominant; collagen alpha-1(III) chain; collagen, fetal; alpha1 (III) collagen; Ehlers-Danlos syndrome type IV, autosomal dominant; EDS4A; FLJ34534;
Gene ID : 1281
mRNA Refseq : NM_000090
Protein Refseq : NP_000081
MIM : 120180
UniProt ID : P02461
Chromosome Location : 2q32.2
Pathway : Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; ECM-receptor interaction, organism-specific biosystem; ECM-receptor interaction, conserved biosystem; Endothelins, organism-specific biosystem;
Function : SMAD binding; extracellular matrix structural constituent; integrin binding; integrin binding; platelet-derived growth factor binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How can the study of COL3A1 protein aid in the development of personalized medicine for vEDS patients? 04/12/2023

Understanding the specific genetic and protein alterations in vEDS patients can help tailor individualized treatment strategies based on the patient's unique molecular profile.

Can COL3A1 protein analysis be used for prenatal screening of vEDS? 07/05/2022

Yes, analysis of COL3A1 protein levels in prenatal samples may provide valuable information for assessing the risk of vEDS in the developing fetus.

How can the measurement of COL3A1 protein levels aid in the early detection of vEDS? 03/28/2021

Elevated or decreased levels of COL3A1 protein may serve as potential biomarkers for early detection and risk assessment of vEDS, especially in at-risk individuals or families.

What are the current challenges in the clinical application of COL3A1 protein analysis? 01/08/2020

Challenges include the need for standardized assays and reference ranges for COL3A1 protein levels, as well as the interpretation of results in the context of individual patient variability.

Can the measurement of COL3A1 protein levels be used to monitor disease progression in vEDS patients? 12/31/2019

Yes, monitoring changes in COL3A1 protein levels may provide insights into disease progression and response to treatment in vEDS patients.

Customer Reviews (3)

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Reviews
01/23/2020

    This protein demonstrates great performance in WB assays, providing accurate and reliable results that are crucial for protein analysis.

    05/08/2019

      The COL3A1 protein is of exceptional quality, making it an ideal choice to meet my experimental needs.

      07/27/2016

        the COL3A1 protein has proven to be an invaluable tool in protein electron microscopy (EM) structure analysis.

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