Recombinant Human CREBBP protein, His-tagged
Cat.No. : | CREBBP-193H |
Product Overview : | Recombinant Human CREBBP(a.a: 1081–1197) fused with His tag at N-terminal was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, and 10% glycerol |
Molecular Mass : | 14.9 kDa |
AA Sequence : | MHHHHHHRKKIFKPEELRQALMPTL EALYRQDPESLPFRQPVDPQLLGIP DYFDIVKNPMDLSTIKRKLDTGQY QEPWQYVDDVWLMFNNAWLYNRKTS RVYKFCSKLAEVFEQEIDPVMQSLG |
Purity : | > 98% |
Applications : | Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling. |
Storage : | >6 months at –80 centigrade. Avoid freeze/thaw cycles. |
Concentration : | 1.26 mg/ml |
Gene Name : | CREBBP CREB binding protein [ Homo sapiens ] |
Official Symbol : | CREBBP |
Synonyms : | CREBBP; CREB binding protein; RSTS, Rubinstein Taybi syndrome; CREB-binding protein; CBP; KAT3A; RTS; RSTS; |
Gene ID : | 1387 |
mRNA Refseq : | NM_004380 |
Protein Refseq : | NP_004371 |
MIM : | 600140 |
UniProt ID : | Q92793 |
Chromosome Location : | 16p13.3 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Angiogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Cell cycle, organism-specific biosystem; |
Products Types
◆ Recombinant Protein | ||
CREBBP-1852H | Recombinant Human CREBBP Protein, GST-tagged | +Inquiry |
CREBBP-001H | Recombinant Human CREBBP Protein, GST-tagged | +Inquiry |
CREBBP-01D | Recombinant Dog Crebbp Protein, His tagged | +Inquiry |
CREBBP-1022R | Recombinant Monkey Crebbp Protein, His tagged | +Inquiry |
CREBBP-22HCL | Recombinant Human CREBBP 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1710 | CREBBP Inhibitor Screening Assay Kit | +Inquiry |
Kit-1711 | CREBBP TR-FRET Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (7)
Ask a questionDiscovering novel CREBBP inhibitors is crucial due to the limited number of reported inhibitors, and there is a need to enhance the activity and selectivity of existing compounds.
The bromodomain in CREBBP is linked to its involvement in cancer and other disease processes.
CREBBP stands for CREB-binding protein.
CREBBP serves as a coactivator for the cAMP response element-binding protein (CREB) transcription factor. It plays a crucial role in gene activation.
Research on small molecule inhibitors of CREBBP is in its early stages, with only a few inhibitors reported. Improvements in activity and selectivity are needed for these compounds.
CREBBP belongs to the third category of structural domain proteins, and it shares homology with its counterpart EP300.
CREBBP contains a bromodomain, which is associated with the development of cancer and other diseases.
Customer Reviews (3)
Write a reviewThe product's adaptability to custom protocols empowered us to explore innovative experimental setups.
The reduced environmental impact of the product was a responsible choice that resonated with our values.
Customized solutions offered by the manufacturer increased the product's utility in our research.
Ask a Question for All CREBBP Products
Required fields are marked with *
My Review for All CREBBP Products
Required fields are marked with *
Inquiry Basket