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Recombinant Human CRTC3 protein, GST-tagged

Cat.No. : CRTC3-32H
Product Overview : Recombinant Human CRTC3(176 a.a. - 274 a.a.) fused with GST tag at N-terminal was expressed in Wheat Germ.
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Description : This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Source : Wheat Germ
Species : Human
Tag : GST
Form : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 36.63 kDa
AA Sequence : QDPYGGGGQSAWPAPYMGFCDGENN GHGEVASFPGPLKEENLLNVPKPLP KQLWETKEIQSLSGRPRSCDVGGGN AFPHNGQNLGLSPFLGTLNTGGSL
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : CRTC3 CREB regulated transcription coactivator 3 [ Homo sapiens ]
Official Symbol : CRTC3
Synonyms : CRTC3; CREB regulated transcription coactivator 3; CREB-regulated transcription coactivator 3; FLJ21868; TORC-3; transducer of CREB protein 3; transducer of regulated CREB protein 3; transducer of regulated cAMP response element-binding protein 3; transducer of regulated cAMP response element-binding protein (CREB) 3; TORC3;
Gene ID : 64784
mRNA Refseq : NM_022769
Protein Refseq : NP_073606
MIM : 608986
UniProt ID : Q6UUV7
Chromosome Location : 15q26.1
Pathway : HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;
Function : cAMP response element binding protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any therapeutic implications for targeting CRTC3 in metabolic diseases? 11/30/2021

Modulating CRTC3 activity has shown promise as a potential therapeutic approach for treating metabolic diseases, though more research is needed.

How does CRTC3 participate in the regulation of glucose metabolism? 01/18/2020

CRTC3 is involved in glucose homeostasis by influencing the expression of genes related to gluconeogenesis and glucose uptake.

Can targeting CRTC3 be a strategy for cancer therapy? 01/05/2018

Research suggests that targeting CRTC3 may have therapeutic potential in certain cancers, but further studies are required to validate this approach.

Are there any diagnostic applications of CRTC3 in clinical settings? 01/09/2017

The potential diagnostic applications of CRTC3 are still under exploration, but its altered expression levels may serve as biomarkers for certain conditions.

Could manipulating CRTC3 be a potential avenue for neuroprotective therapies? 08/05/2016

Modulating CRTC3 activity may hold promise for neuroprotective strategies, but the specific mechanisms and applications require more investigation.

Customer Reviews (3)

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Reviews
06/26/2022

    The CRTC3 protein's versatility extends beyond its use in vitro experiments.

    03/20/2020

      With the CRTC3 protein as a research tool, achieving meaningful scientific findings becomes an accessible and achievable goal.

      08/31/2019

        Their expertise and dedication enable them to effectively address and resolve any technical issues that may arise during experimentation.

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