Recombinant Human DICER1 protein, MYC/DDK-tagged
Cat.No. : | DICER1-784H |
Product Overview : | Recombinant Human DICER1, transcript variant 2, fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene ex |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 218.5 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | DICER1 dicer 1, ribonuclease type III [ Homo sapiens ] |
Official Symbol : | DICER1 |
Synonyms : | DICER1; dicer 1, ribonuclease type III; Dicer1, Dcr 1 homolog (Drosophila); endoribonuclease Dicer; Dicer; dicer 1; double stranded RNA specific endoribonuclease; HERNA; K12H4.8 LIKE; KIAA0928; K12H4.8-LIKE; helicase MOI; helicase-moi; Dicer1, Dcr-1 homolog; helicase with RNAse motif; dicer 1, double-stranded RNA-specific endoribonuclease; DCR1; MNG1; |
Gene ID : | 23405 |
mRNA Refseq : | NM_030621 |
Protein Refseq : | NP_085124 |
MIM : | 606241 |
UniProt ID : | Q9UPY3 |
Chromosome Location : | 14q32.2 |
Pathway : | Gene ex |
Function : | ATP binding; ATP-dependent helicase activity; double-stranded RNA binding; endonuclease activity; helicase activity; hydrolase activity; metal ion binding; miRNA binding; nucleotide binding; protein binding; ribonuclease III activity; ribonuclease III activity; |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionDICER1 mutations may also lead to non-cancer conditions, such as pleuropulmonary blastoma syndrome and cystic nephroma.
Research is ongoing to explore whether targeting DICER1-related pathways could lead to novel cancer treatments.
Yes, some diagnostic tests can measure DICER1 expression, which may be relevant in certain cancer types.
Yes, DICER1 mutations can be passed down through families and cause a hereditary predisposition to certain cancers.
DICER1 mutations or dysregulation can lead to abnormal microRNA processing, contributing to the development of cancer.
Customer Reviews (3)
Write a reviewIts purity and functional integrity guarantee optimal performance in a wide range of experimental applications.
Their team of experts is readily available to assist you with any inquiries or challenges you may encounter during your experiments.
This protein, manufactured with utmost precision, provides reliable and consistent results, ensuring the accuracy and reproducibility of your research findings.
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