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Recombinant Human DICER1 protein, MYC/DDK-tagged

Cat.No. : DICER1-784H
Product Overview : Recombinant Human DICER1, transcript variant 2, fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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  • Gene Information
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Description : This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 218.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : DICER1 dicer 1, ribonuclease type III [ Homo sapiens ]
Official Symbol : DICER1
Synonyms : DICER1; dicer 1, ribonuclease type III; Dicer1, Dcr 1 homolog (Drosophila); endoribonuclease Dicer; Dicer; dicer 1; double stranded RNA specific endoribonuclease; HERNA; K12H4.8 LIKE; KIAA0928; K12H4.8-LIKE; helicase MOI; helicase-moi; Dicer1, Dcr-1 homolog; helicase with RNAse motif; dicer 1, double-stranded RNA-specific endoribonuclease; DCR1; MNG1;
Gene ID : 23405
mRNA Refseq : NM_030621
Protein Refseq : NP_085124
MIM : 606241
UniProt ID : Q9UPY3
Chromosome Location : 14q32.2
Pathway : Gene expression, organism-specific biosystem; MicroRNA (miRNA) Biogenesis, organism-specific biosystem; Regulatory RNA pathways, organism-specific biosystem; Small Interfering RNA (siRNA) Biogenesis, organism-specific biosystem; mRNA processing, organism-specific biosystem;
Function : ATP binding; ATP-dependent helicase activity; double-stranded RNA binding; endonuclease activity; helicase activity; hydrolase activity; metal ion binding; miRNA binding; nucleotide binding; protein binding; ribonuclease III activity; ribonuclease III activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can DICER1 mutations affect non-cancer-related health conditions? 07/21/2021

DICER1 mutations may also lead to non-cancer conditions, such as pleuropulmonary blastoma syndrome and cystic nephroma.

Is there any potential for using DICER1 in targeted cancer therapies? 06/23/2021

Research is ongoing to explore whether targeting DICER1-related pathways could lead to novel cancer treatments.

Are there any clinical tests or assays that measure DICER1 levels in patients? 01/21/2020

Yes, some diagnostic tests can measure DICER1 expression, which may be relevant in certain cancer types.

Can DICER1 mutations be hereditary? 02/09/2019

Yes, DICER1 mutations can be passed down through families and cause a hereditary predisposition to certain cancers.

How is DICER1 involved in cancer development and progression? 03/09/2018

DICER1 mutations or dysregulation can lead to abnormal microRNA processing, contributing to the development of cancer.

Customer Reviews (3)

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Reviews
04/26/2023

    Its purity and functional integrity guarantee optimal performance in a wide range of experimental applications.

    10/26/2018

      Their team of experts is readily available to assist you with any inquiries or challenges you may encounter during your experiments.

      03/28/2018

        This protein, manufactured with utmost precision, provides reliable and consistent results, ensuring the accuracy and reproducibility of your research findings.

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