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Recombinant Human EEA1 protein, MYC/DDK-tagged

Cat.No. : EEA1-26H
Product Overview : Recombinant Human EEA1 fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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Description : Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 162.3 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : EEA1 early endosome antigen 1 [ Homo sapiens ]
Official Symbol : EEA1
Synonyms : EEA1; early endosome antigen 1; early endosome antigen 1, 162kD; ZFYVE2; endosome-associated protein p162; early endosome-associated protein; zinc finger FYVE domain-containing protein 2; MST105; MSTP105;
Gene ID : 8411
mRNA Refseq : NM_003566
Protein Refseq : NP_003557
MIM : 605070
UniProt ID : Q15075
Chromosome Location : 12q22
Pathway : Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem;
Function : 1-phosphatidylinositol binding; GTP-dependent protein binding; calmodulin binding; metal ion binding; protein binding; protein homodimerization activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does EEA1 protein relate to neurodegenerative disorders? 11/19/2022

EEA1 protein has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, where abnormal endosome trafficking may contribute to disease progression.

Are there any diagnostic applications of EEA1 protein in neurodegenerative disorders? 10/27/2022

EEA1 protein expression and localization may serve as a potential diagnostic marker for certain neurodegenerative disorders, offering insights into disease pathology.

Can targeting EEA1 protein offer potential therapeutic avenues for neurodegenerative disorders? 06/22/2019

Research suggests that modulating EEA1 protein function may hold promise as a therapeutic approach for neurodegenerative disorders, although further investigation is needed.

How does EEA1 protein function in infectious diseases? 06/09/2019

EEA1 protein plays a critical role in the intracellular trafficking of pathogens, including viruses and bacteria, and its dysregulation can impact the outcome of infectious diseases.

How is EEA1 protein expressed in cancer cells? 12/21/2018

In cancer cells, EEA1 protein expression levels can be altered, leading to abnormal endosome trafficking and potential implications for tumor growth and metastasis.

Customer Reviews (3)

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Reviews
10/04/2020

    In protein electron microscopy structure analysis, the EEA1 protein demonstrates outstanding performance.

    09/25/2020

      the EEA1 protein's versatility allows it to be effectively employed in various experimental designs, further enhancing its suitability for diverse research needs.

      02/09/2020

        Their extensive knowledge and expertise can help troubleshoot issues or provide guidance on experimental design, enabling you to overcome obstacles and achieve your research goals.

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