Recombinant Human EEA1 protein, MYC/DDK-tagged
Cat.No. : | EEA1-26H |
Product Overview : | Recombinant Human EEA1 fused with MYC/DDK tag at C-terminal was expressed in HEK293. |
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- Gene Information
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Description : | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
Source : | HEK293 |
Species : | Human |
Tag : | MYC/DDK |
Form : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 162.3 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | EEA1 early endosome antigen 1 [ Homo sapiens ] |
Official Symbol : | EEA1 |
Synonyms : | EEA1; early endosome antigen 1; early endosome antigen 1, 162kD; ZFYVE2; endosome-associated protein p162; early endosome-associated protein; zinc finger FYVE domain-containing protein 2; MST105; MSTP105; |
Gene ID : | 8411 |
mRNA Refseq : | NM_003566 |
Protein Refseq : | NP_003557 |
MIM : | 605070 |
UniProt ID : | Q15075 |
Chromosome Location : | 12q22 |
Pathway : | Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem; |
Function : | 1-phosphatidylinositol binding; GTP-dependent protein binding; calmodulin binding; metal ion binding; protein binding; protein homodimerization activity; zinc ion binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionEEA1 protein has been implicated in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, where abnormal endosome trafficking may contribute to disease progression.
EEA1 protein expression and localization may serve as a potential diagnostic marker for certain neurodegenerative disorders, offering insights into disease pathology.
Research suggests that modulating EEA1 protein function may hold promise as a therapeutic approach for neurodegenerative disorders, although further investigation is needed.
EEA1 protein plays a critical role in the intracellular trafficking of pathogens, including viruses and bacteria, and its dysregulation can impact the outcome of infectious diseases.
In cancer cells, EEA1 protein expression levels can be altered, leading to abnormal endosome trafficking and potential implications for tumor growth and metastasis.
Customer Reviews (3)
Write a reviewIn protein electron microscopy structure analysis, the EEA1 protein demonstrates outstanding performance.
the EEA1 protein's versatility allows it to be effectively employed in various experimental designs, further enhancing its suitability for diverse research needs.
Their extensive knowledge and expertise can help troubleshoot issues or provide guidance on experimental design, enabling you to overcome obstacles and achieve your research goals.
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