Active Recombinant Human EGFR Protein, His-tagged
Cat.No. : | EGFR-155H |
Product Overview : | Recombinant Human EGFR (C775S T790M L858R) (668-end), transcript variant 1, fused with His tag at N-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. |
Source : | Insect cells |
Species : | Human |
Tag : | His |
Form : | 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol |
Bio-activity : | 15 nmol/min/mg |
Molecular Mass : | 89~100 kDa |
Purity : | > 70% |
Applications : | Kinase Assay |
Stability : | 1 year at -70 centigrade from date of shipment. |
Storage : | Store product at –70centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.1 ug/ml |
Gene Name : | EGFR epidermal growth factor receptor [ Homo sapiens ] |
Official Symbol : | EGFR |
Synonyms : | EGFR; epidermal growth factor receptor; epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) , ERBB; ERBB1; erythroblastic leukemia viral (v erb b) oncogene homolog (avian); proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; ERBB; HER1; mENA; PIG61; |
Gene ID : | 1956 |
mRNA Refseq : | NM_005228 |
Protein Refseq : | NP_005219 |
MIM : | 131550 |
UniProt ID : | P00533 |
Products Types
◆ Recombinant Protein | ||
EGFR-292E | Active Recombinant Human EGFR Protein, His-tagged | +Inquiry |
EGFR-1373H | Recombinant Human EGFR Protein, His-tagged | +Inquiry |
EGFR-0974H | Recombinant Human EGFR Protein (L25-A1210), eGFP, Strep II, 10×His tagged | +Inquiry |
EGFR-25H | Recombinant Active Human EGFR (D770_N771insY) Mutant Protein, GST-tagged | +Inquiry |
EGFR-213H | Recombinant Human EGFR Protein, Strep-tagged | +Inquiry |
◆ Lysates | ||
EGFR-1621MCL | Recombinant Mouse EGFR cell lysate | +Inquiry |
EGFR-1462RCL | Recombinant Rat EGFR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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