"EHMT1" Related Products

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Recombinant Human EHMT1 protein, GST-tagged, Active

Cat.No.: EHMT1-181H
Product Overview: Recombinant Human EHMT1(895-end) fused with GST tag at N-terminal was expressed in Insect cells.
Description: Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) is in charge of the mono- and demethylation of lysine-9 of histone H3. EHMT1 is found in a multimeric protein complex containing chromatin modifiers, which contributes to silencing of MYC- and E2F-responsive genes during G0 phase of cell cycle. EHMT1 plays a role in epithelial-to-mesenchymal transition and tumor invasion by repressing expression of tumour suppressor genes. Additionally, EHMT1 also methylates non-histone proteins such as lysine-373 of p53.
Source: Insect cells
Species: Human
Tag : GST
Form: 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 380 nmol/min/mg
Molecular Mass: 74 kDa
Purity: >95%
Applications: Methyltransferase Assay
Stability: 1 year at -70 centigrade from the date of shipment
Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: EHMT1 euchromatic histone-lysine N-methyltransferase 1 [ Homo sapiens ]
Official Symbol: EHMT1
Synonyms: EHMT1; euchromatic histone-lysine N-methyltransferase 1; euchromatic histone methyltransferase 1; histone-lysine N-methyltransferase EHMT1; bA188C12.1; Eu HMTase1; FLJ12879; KIAA1876; KMT1D; H3-K9-HMTase 5; G9a like protein; G9a-like protein 1; lysine N-m
Gene ID: 79813
mRNA Refseq: NM_024757
Protein Refseq: NP_079033
MIM: 607001
UniProt ID: Q9H9B1
Chromosome Location: 9
Pathway: Lysine degradation, organism-specific biosystem; Lysine degradation, conserved biosystem;
Function: histone methyltransferase activity (H3-K27 specific); histone methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; p53 binding; protein binding; protein-lysine N-methyltransferase activity; transferase activity; zinc ion binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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