Active Recombinant Human ERBB3 protein, Twin-Strep-tagged
Cat.No. : | ERBB3-45H |
Product Overview : | Recombinant Human ERBB3 protein(Ser 20 - Thr 643), fused with Twin-Strep tag, was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Source : | HEK293 |
Species : | Human |
Tag : | Twin-Strep |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization. |
Bio-activity : | Immobilized Human ErbB3 Protein, Twin-Strep Tag at 2 μg/mL (100 μL/well) can bind Human NRG1 Beta 1, Fc Tag with a linear range of 0.5-8 ng/mL. |
Molecular Mass : | This protein carries a twin strep tag at the C-terminus.The protein has a calculated MW of 71.7 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein Length : | Ser20-Thr643 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term, the product should be stored at lyophilized state at -20°C or lower.Please protect from light and avoid repeated freeze-thaw cycles.This product is stable after at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homo sapiens ] |
Official Symbol : | ERBB3 |
Synonyms : | ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033; |
Gene ID : | 2065 |
mRNA Refseq : | NM_001005915 |
Protein Refseq : | NP_001005915 |
MIM : | 190151 |
UniProt ID : | P21860 |
Products Types
◆ Recombinant Protein | ||
ERBB3-2117H | Recombinant Human ERBB3 Protein, MYC/DDK-tagged | +Inquiry |
ERBB3-858H | Recombinant Human ERBB3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ERBB3-3448H | Recombinant Human ERBB3 Protein, GST-tagged | +Inquiry |
ERBB3-238H | Recombinant Human ERBB3 Protein, Strep-tagged | +Inquiry |
ERBB3-7276H | Active Recombinant Human ERBB3 protein(Pro 730-Ser 1065), His&GST-tagged | +Inquiry |
◆ Lysates | ||
ERBB3-1765MCL | Recombinant Mouse ERBB3 cell lysate | +Inquiry |
ERBB3-939HCL | Recombinant Human ERBB3 cell lysate | +Inquiry |
ERBB3-1415RCL | Recombinant Rat ERBB3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPotential side effects may include skin rash, diarrhea, and cardiovascular issues, as seen with other drugs targeting the EGFR family.
ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.
ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.
Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.
ERBB3 overexpression is frequently observed in breast, ovarian, and gastric cancers, among others.
Customer Reviews (3)
Write a reviewTheir expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.
Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.
The ERBB3 protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.
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