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Active Recombinant Human ERBB3 protein, Twin-Strep-tagged

Cat.No. : ERBB3-45H
Product Overview : Recombinant Human ERBB3 protein(Ser 20 - Thr 643), fused with Twin-Strep tag, was expressed in HEK293.
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  • Gene Information
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Source : HEK293
Species : Human
Tag : Twin-Strep
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Bio-activity : Immobilized Human ErbB3 Protein, Twin-Strep Tag at 2 μg/mL (100 μL/well) can bind Human NRG1 Beta 1, Fc Tag with a linear range of 0.5-8 ng/mL.
Molecular Mass : This protein carries a twin strep tag at the C-terminus.The protein has a calculated MW of 71.7 kDa. The protein migrates as 85-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein Length : Ser20-Thr643
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term, the product should be stored at lyophilized state at -20°C or lower.Please protect from light and avoid repeated freeze-thaw cycles.This product is stable after at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homo sapiens ]
Official Symbol : ERBB3
Synonyms : ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033;
Gene ID : 2065
mRNA Refseq : NM_001005915
Protein Refseq : NP_001005915
MIM : 190151
UniProt ID : P21860

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the potential side effects of targeting ERBB3 in cancer therapy? 03/08/2023

Potential side effects may include skin rash, diarrhea, and cardiovascular issues, as seen with other drugs targeting the EGFR family.

How does ERBB3 contribute to resistance to certain cancer therapies? 01/29/2023

ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.

How does ERBB3 interact with other receptors in the EGFR family? 11/07/2022

ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.

Can ERBB3 be used as a biomarker for prognosis in cancer patients? 10/26/2022

Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.

In which types of cancers is ERBB3 commonly overexpressed? 10/19/2020

ERBB3 overexpression is frequently observed in breast, ovarian, and gastric cancers, among others.

Customer Reviews (3)

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Reviews
10/28/2021

    Their expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.

    08/11/2021

      Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.

      03/03/2020

        The ERBB3 protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.

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