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Recombinant Human FASN protein, MYC/DDK-tagged

Cat.No. : FASN-138H
Product Overview : Recombinant Human FASN fused with MYC/DDK tag at C-terminal was expressed in HEK293.
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  • Gene Information
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Description : The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 273.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : FASN fatty acid synthase [ Homo sapiens ]
Official Symbol : FASN
Synonyms : FASN; fatty acid synthase; FAS; SDR27X1; short chain dehydrogenase/reductase family 27X; member 1; short chain dehydrogenase/reductase family 27X, member 1; OA-519; MGC14367; MGC15706;
Gene ID : 2194
mRNA Refseq : NM_004104
Protein Refseq : NP_004095
MIM : 600212
UniProt ID : P49327
Chromosome Location : 17q25
Pathway : ChREBP activates metabolic gene expression, organism-specific biosystem; Fatty Acid Biosynthesis, organism-specific biosystem; Fatty Acyl-CoA Biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, organism-specific biosystem; Fatty acid biosynthesis, conserved biosystem; Fatty acid biosynthesis, elongation, organism-specific biosystem; Fatty acid biosynthesis, elongation, conserved biosystem;
Function : 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; 3-oxoacyl-[acyl-carrier-protein] synthase activity; [acyl-carrier-protein] S-acetyltransferase activity; [acyl-carrier-protein] S-malonyltransferase activity; acyl carrier activity; cofactor binding; enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; fatty acid synthase activity; hydrolase activity, acting on ester bonds; lyase activity; myristoyl-[acyl-carrier-protein] hydrolase activity; nucleotide binding; oleoyl-[acyl-carrier-protein] hydrolase activity; oxidoreductase activity; palmitoyl-[acyl-carrier-protein] hydrolase activity; phosphopantetheine binding; protein binding; transferase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing clinical trials targeting FASN for therapeutic purposes? 12/03/2022

Yes, several clinical trials are investigating FASN inhibitors as potential treatments for cancer and metabolic disorders.

How does FASN relate to insulin resistance and diabetes? 10/17/2020

FASN has been associated with insulin resistance, and its inhibition is being investigated as a potential avenue for treating insulin resistance and type 2 diabetes.

Can FASN inhibitors be used in combination with other cancer therapies? 08/03/2020

Combination therapies involving FASN inhibitors and other anticancer drugs are being explored to enhance treatment efficacy and reduce potential resistance.

How does FASN influence the development and progression of obesity? 01/31/2018

FASN is involved in the synthesis of fatty acids, and its dysregulation can contribute to excessive fat accumulation, potentially leading to obesity.

Does FASN play a role in neurodegenerative diseases? 04/27/2016

Emerging research suggests a potential link between FASN and neurodegenerative diseases, but more studies are needed to fully understand this connection.

Customer Reviews (3)

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Reviews
12/13/2022

    Its high quality and purity ensure accurate and reliable results.

    07/26/2017

      With the manufacturer's unwavering dedication to delivering quality products and unparalleled technical support, I am confident in their ability to help me overcome any challenges and propel my research forward.

      06/20/2017

        The FASN protein exhibits several valuable attributes that make it an excellent choice for my trials.

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