Recombinant Human FOXP3 protein, His-tagged

• Cat.No.: FOXP3-53H
• Product Overview: Recombinant Human FOXP3, transcript variant 2, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl.
• Molecular Mass: 43.2 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: FOXP3 forkhead box P3 [ Homo sapiens ]
• Official Symbol: FOXP3
• Synonyms: FOXP3; forkhead box P3; immune dysregulation, polyendocrinopathy, enteropathy, X linked , IPEX; forkhead box protein P3; AIID; DIETER; JM2; PIDX; SCURFIN; XPID; scurfin; FOXP3delta7; immunodeficiency, polyendocrinopathy, enteropathy, X-linked; immune dysregulation, polyendocrinopathy, enteropathy, X-linked; IPEX; MGC141961; MGC141963
• Gene ID: 50943
• mRNA Refseq: NM_001114377
• Protein Refseq: NP_001107849
• MIM: 300292
• UniProt ID: Q9BZS1
• Chromosome Location: Xp11.23
• Pathway: Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; IL2 signaling events mediated by STAT5, organism-specific biosystem
• Function: DNA binding, bending; NF-kappaB binding; NFAT protein binding; chromatin binding; double-stranded DNA binding; histone acetyltransferase binding; histone deacetylase binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding