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Recombinant Human HAMP protein, His & Fc-tagged

Cat.No. : HAMP-458H
  • Specification
  • Gene Information
  • Related Products
Product overview : Recombinant Human HAMP (P81172) aa. (Ser25~Thr84) fused with His & Fc tag was produced in HEK293F cells.
Description : The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity against bacteria and fungi. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results in cardiomyopathy, cirrhosis, and endocrine failure.
Source : HEK293F
Species : Human
Tag : His & Fc
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 34.1kDa; Accurate Molecular Mass: 33&40kDa as determined by SDS-PAGE reducing conditions.
Protein length : Ser25~Thr84
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 95%
Characteristic : Isoelectric point is 9.4.
Applications : SDS-PAGE; WB; ELISA; IP; CoIP; EMSA; Reporter Assays; Purification; Amine Reactive Labeling
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Concentration : 200ug/mL
Storage buffer : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex
Gene Name : HAMP hepcidin antimicrobial peptide [ Homo sapiens (human) ]
Official Symbol : HAMP
Synonyms : HAMP; hepcidin antimicrobial peptide; HEPC; PLTR; HFE2B; LEAP1; hepcidin; liver-expressed antimicrobial peptide 1; putative liver tumor regressor
Gene ID : 57817
mRNA Refseq : NM_021175.3
Protein Refseq : NP_066998.1
UniProt ID : P81172

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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