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Recombinant Human HAO1 protein, His-tagged

Cat.No. : HAO1-378H
Product Overview : Recombinant Human HAO1 protein (Leu2-Ile370), fused to His tag at N-terminus, was expressed in human 293 cells (HEK293).
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  • Gene Information
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Description : Hydroxyacid oxidase 1 (HAO-1), a member of the FMN-dependent alpha-hydroxy acid dehydrogenase family, is also known as glycolate oxidase (GOX), which contains 1 FMN hydroxy acid dehydrogenase domain. HAO-1 Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 um filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 41.7 kDa. The protein migrates as 41.7 kDa under reducing (R) condition (SDS-PAGE).
Protein length : 369
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : HAO1
Official Symbol : HAO1
Synonyms : HAO1; hydroxyacid oxidase (glycolate oxidase) 1; GOX1; hydroxyacid oxidase 1; GOX; glycolate oxidase; (S)-2-hydroxy-acid oxidase; HAOX1; MGC142225; MGC142227
Gene ID : 54363
mRNA Refseq : NM_017545
Protein Refseq : NP_060015
MIM : 605023
UniProt ID : Q9UJM8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is HAO1 implicated in metabolic disorders? 02/14/2022

Dysregulation of HAO1 is linked to metabolic disorders and fatty liver disease.

Are there existing or potential therapeutic strategies targeting HAO1? 09/04/2021

Therapeutic approaches may include modulation of HAO1 activity or expression.

How does HAO1 contribute to fatty acid metabolism? 08/15/2020

It oxidizes specific fatty acids, contributing to their breakdown.

What are the key biological functions of HAO1? 07/14/2020

HAO1 is involved in peroxisomal fatty acid oxidation, crucial for lipid metabolism.

What are the potential consequences of HAO1 overexpression? 06/15/2020

HAO1 overexpression may lead to oxidative stress and liver dysfunction.

What role does HAO1 play in liver function? 01/01/2019

HAO1 supports liver function by participating in lipid catabolism.

How is HAO1 activity regulated in cells? 10/13/2018

Cellular regulation of HAO1 involves transcriptional and post-translational mechanisms.

Customer Reviews (3)

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Reviews
05/09/2022

    Worked well in experiments.

    11/28/2020

      Great for academic research.

      01/28/2020

        Very satisfied, will buy again.

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