Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human HDAC2 protein, His-tagged

Cat.No. : HDAC2-393H
Product Overview : Recombinant Human HDAC2 fused with His tag was expressed in Insect cells.
  • Specification
  • Gene Information
  • Related Products
Description : HDAC2 is a member of the histone deacetylase family that performs through the construction of large multiprotein complexes and are in charge of the deacetylation of lysine residues on the N-terminal region of the core histones. HDAC2 forms transcriptional repressor complexes by relating to a diversity of proteins, like YY1- a mammalian zinc-finger transcription factor. Additionally, HDAC2 has a vital part in transcriptional regulation, cell cycle progression and developmental procedures.
Source : Insect cells
Species : Human
Tag : His
Form : The HDAC2 solution contains 20 mM Tris-HCl buffer (pH 8.0), 300 mM NaCl and 20% Glycerol. Frozen solution.
Bio-activity : > 500 pmol/min/μg
Molecular Mass : 56.2 kDa, observed by reducing SDS-PAGE.
AA Sequence : MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTHNLLLNYGLYR KMEIYRPHKA TAEEMTKYHS DEYIKFLRSIRPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA
GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLAILELLKYHQR VLYIDIDIHH GDGVEEAFYT TDRVMTVSFHKYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ
IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVKGHAKCVEVVK TFNLPLLMLG GGGYTIRNVA RCWTYETAVALDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM
EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGEDPDKRISIRA SDKRIACDEE FSDSEDEGEG GRRNVADHKKGAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDTKGT
KSEQLSNPGH HHHHH
Endotoxin : < 1 EU/μg, determined by LAL method.
Purity : > 80% by SDS-PAGE analysis.
Storage : HDAC2 remains stable up to 6 months at -80 centigrade from date of receipt. For maximum recovery of product, centrifuge original vial prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Publication :
Circumvention of Gefitinib Resistance by Repurposing Flunarizine via Histone Deacetylase Inhibition (2023)
Gene Name : HDAC2 histone deacetylase 2 [ Homo sapiens ]
Official Symbol : HDAC2
Synonyms : HDAC2; histone deacetylase 2; RPD3; YAF1; YY1-associated factor 1; transcriptional regulator homolog RPD3; HD2;
Gene ID : 3066
mRNA Refseq : NM_001527
Protein Refseq : NP_001518
MIM : 605164
UniProt ID : Q92769
Chromosome Location : 6q21
Pathway : Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem;
Function : NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); chromatin binding; enzyme binding; histone deacetylase activity; histone deacetylase activity (H3-K16 specific); hydrolase activity; protein binding; protein deacetylase activity; sequence-specific DNA binding; transcription factor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can HDAC2 be a potential biomarker for certain diseases? 08/13/2022

Research suggests that HDAC2 levels can serve as a biomarker for certain diseases, aiding in diagnosis and prognosis.

Are there HDAC inhibitors used in clinical settings? 07/16/2022

Yes, HDAC inhibitors are being explored as a therapeutic strategy in cancer treatment, aiming to block the activity of HDAC2.

How does HDAC2 impact cancer progression? 06/24/2021

HDAC2 is often overexpressed in cancer cells, contributing to uncontrolled cell growth and survival.

How does HDAC2 influence cellular processes through histone deacetylation? 07/27/2018

HDAC2 removes acetyl groups from histones, leading to chromatin condensation and repression of gene transcription, affecting cellular processes.

How does HDAC2 relate to neurodegenerative disorders? 10/23/2016

HDAC2 dysregulation has been observed in neurodegenerative diseases, suggesting a role in the pathogenesis of conditions like Alzheimer's.

Customer Reviews (3)

Write a review
Reviews
11/23/2021

    Its versatility allows for its successful implementation in diverse areas such as molecular biology, cellular assays, and protein-protein interactions.

    11/16/2018

      This adaptability ensures that the HDAC2 protein can effectively address my specific research objectives, enabling breakthrough discoveries.

      08/22/2018

        the HDAC2 protein exhibits superior performance across a range of experimental applications.

        Ask a Question for All HDAC2 Products

        Required fields are marked with *

        My Review for All HDAC2 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends