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Recombinant Human HDAC6 protein, His-tagged

Cat.No. : HDAC6-131H
Product Overview : Recombinant Human HDAC6(Val166~Leu348) fused with His tag at N-terminal was expressed in E. coli.
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Description : Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300
Molecular Mass : 22.0kDa
Protein length : Val166~Leu348
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others.
Gene Name : HDAC6 histone deacetylase 6 [ Homo sapiens ]
Official Symbol : HDAC6
Synonyms : HDAC6; histone deacetylase 6; FLJ16239; HD6; JM21; KIAA0901;
Gene ID : 10013
mRNA Refseq : NM_006044
Protein Refseq : NP_006035
MIM : 300272
UniProt ID : Q9UBN7
Chromosome Location : Xp11.23
Pathway : Cell cycle, organism-specific biosystem; NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by NOTCH, organism-specific biosystem; Signaling by NOTCH1, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem;
Function : Hsp90 protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); actin binding; alpha-tubulin binding; beta-catenin binding; beta-tubulin binding; dynein complex binding; enzyme binding; histone deacetylase activity; histone deacetylase activity (H3-K16 specific); histone deacetylase binding; hydrolase activity; metal ion binding; microtubule binding; microtubule binding; polyubiquitin binding; protein binding; tau protein binding; tubulin deacetylase activity; tubulin deacetylase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can HDAC6 inhibitors be used in combination with other therapies, and if so, what synergistic effects are expected? 06/19/2022

Yes, HDAC6 inhibitors can be combined with other therapies for enhanced efficacy. Synergistic effects may include improved anti-cancer activity or neuroprotection.

Are there any ongoing clinical trials targeting HDAC6, and if so, what are the potential outcomes for patients? 05/29/2020

Yes, there are clinical trials exploring HDAC6 inhibitors as potential treatments. Positive outcomes could lead to new therapeutic options for patients.

In what other diseases has HDAC6 been implicated, and how might this knowledge be applied clinically? 12/24/2018

HDAC6 is implicated in neurodegenerative diseases and inflammatory disorders. Understanding its role could lead to novel therapeutic approaches for these conditions.

How does HDAC6 influence cellular processes, and why is this relevant in a clinical setting? 12/13/2017

HDAC6 regulates cell motility, protein trafficking, and other processes. Understanding these mechanisms is crucial for developing targeted therapies in various diseases.

Are there any known genetic variations in HDAC6, and how might these impact individual responses to treatments in a clinical setting? 08/22/2016

Genetic variations in HDAC6 may influence individual responses to treatments. Personalized medicine approaches could consider these variations for better outcomes.

Customer Reviews (3)

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Reviews
06/23/2019

    Their expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.

    12/07/2018

      The bands of proteins in Western Blotting experiments were very clear.

      09/16/2018

        Its purity and consistency have provided me with reliable and reproducible results, ensuring the accuracy of my research findings.

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