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Recombinant Human ICOSLG protein, His & T7-tagged

Cat.No. : ICOSLG-7689H
Product Overview : Recombinant Human ICOSLG aa. (Lys23~Thr249 (Accession # O75144)) fused with N-terminal His & T7 tag was produced in E. coli cells.
  • Specification
  • Gene Information
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Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 29.1kDa
Protein length : Lys23~Thr249 (Accession # O75144)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 5.8.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : ICOSLG inducible T-cell costimulator ligand [ Homo sapiens (human) ]
Official Symbol : ICOSLG
Synonyms : B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L; B7 homolog 2; B7 homologue 2; B7-like protein Gl50; B7-related protein 1; inducible T-cell co-stimulator ligand; transmembrane protein B7-H2 ICOS ligand; ICOS ligand
Gene ID : 23308
mRNA Refseq : NM_001283050.1
Protein Refseq : NP_001269979.1
UniProt ID : O75144

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to evaluate the role of icosg proteins in the immune system? 10/06/2022

ICOSLG protein plays an important regulatory role in the immune system. It binds to ICOS receptors on the surface of T cells and promotes the activation and differentiation of T cells, which in turn affects the strength and direction of the immune response.

Which biomolecules can be used as molecular markers for ICOSLG proteins? 02/25/2022

Certain biomolecules can serve as molecular markers of ICOSLG proteins, such as mRNAs or proteins of ICOSLG proteins detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.

What factors need to be considered in drug development for ICOSLG proteins? 12/10/2020

Factors to be considered in drug development for ICOSLG proteins include drug specificity, safety, pharmacokinetic properties, etc. In addition, the dosage form, route of administration, and dosage of the drug need to be considered to develop an effective treatment plan.

What factors can affect the expression of ICOSLG protein? 06/09/2020

A variety of factors can affect the expression of ICOSLG protein, including cytokines, inflammatory factors, immunostimulants, etc. These factors can stimulate or inhibit the expression of ICOSLG protein, which in turn affects the strength and direction of the immune response.

What are the therapeutic strategies for ICOSLG protein? 05/06/2020

Therapeutic strategies targeting ICOSLG proteins include inhibition of its activity, modulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against ICOSLG protein to inhibit its aberrant activity in disease, or the regulation of ICOSLG protein expression through gene knockout or overexpression technology.

How to evaluate the potential of ICOSLG protein as a drug target? 02/21/2020

Assessing the potential of ICOSLG proteins as drug targets requires a comprehensive analysis. Factors to consider include the structure and function of the ICOSLG protein, its role in the immune system, interactions with existing medications, and potential therapeutic efficacy and safety.

Customer Reviews (3)

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Reviews
12/17/2022

    ICOSLG performed very well in the experiments, with reliable and reproducible results.

    11/14/2021

      The stability is very strong, and it can maintain the stability of its structure and function even after a lot of use, which shows its excellent quality and reliability.

      06/30/2020

        The storage conditions are simple, and it will not be denatured even at ultra-low temperatures.

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