Recombinant Human IGF1R protein, Flag-tagged, Biotinylated
Cat.No. : | IGF1R-51H |
Product Overview : | Recombinant Human IGF1R, cytoplasmic domain [959-1367(end) amino acids of accession number NP_000866.1] fused with DYKDDDDK tag at N-terminal was expressed in insect cell and biotinylated. |
- Specification
- Gene Information
- Related Products
Source : | Insect cell |
Species : | Human |
Tag : | Flag |
Form : | 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5 |
Molecular Mass : | 50 kDa |
Purity : | >90% as determined by SDS-PAGE and CBB staining |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Gene Name : | IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ] |
Official Symbol : | IGF1R |
Synonyms : | IGF1R; insulin-like growth factor 1 receptor; CD221; IGFIR; IGFR; JTK13; MGC18216; IGF-I receptor; soluble IGF1R variant 1 |
Gene ID : | 3480 |
mRNA Refseq : | NM_000875 |
Protein Refseq : | NP_000866 |
MIM : | 147370 |
UniProt ID : | P08069 |
Chromosome Location : | 15q26.3 |
Pathway : | Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Apoptosis, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Focal Adhesion, organism-specific biosystem; |
Function : | ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; nucleotide binding; phosphatidylinositol 3-kinase binding; protein binding; protein tyrosine kinase activity; receptor activity; |
Products Types
◆ Recombinant Protein | ||
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IGF1R-1392H | Recombinant Human IGF1R Protein, MYC/DDK-tagged | +Inquiry |
IGF1R-0995H | Recombinant Human IGF1R Protein (S982-K1286), His tagged | +Inquiry |
IGF1R-063H | Recombinant Human IGF1R Protein, C-His-tagged | +Inquiry |
IGF1R-0996H | Recombinant Human IGF1R Protein (S982-K1286), Tag Free | +Inquiry |
◆ Lysates | ||
IGF1R-2928HCL | Recombinant Human IGF1R cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1600 | IGF1R Functional Assay Kit | +Inquiry |
Kit-1601 | HEK 293 IGF1R Bioassay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIGF1R is predominantly localized on the cell membrane, where it acts as a receptor for insulin-like growth factors (IGFs) and insulin.
Downstream signaling pathways activated by IGF1R include the Ras/MAPK pathway and PI3K/Akt pathway, contributing to cell growth and survival.
IGF1R interacts with IGFs and insulin, triggering downstream signaling pathways such as the PI3K/Akt pathway, influencing cell proliferation and survival.
There are potential therapeutic implications related to IGF1R in diseases involving growth signaling, making it a target for drug development.
Dysregulation or abnormal expression of IGF1R is associated with conditions such as cancer and developmental disorders.
Insulin-like growth factor 1 receptor (IGF1R) functions in cellular processes, primarily playing a role in growth signaling.
IGF1R contributes to the regulation of tissue development by influencing cell growth, differentiation, and survival.
Customer Reviews (3)
Write a reviewThe product's exceptional purity facilitated precise quantification, ensuring data consistency.
The product consistently delivered robust and dependable results, affirming its efficacy in our experiments.
The product's consistent performance bolstered the dependability of our research conclusions.
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