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Recombinant Human IKBKB protein, Flag-tagged, Biotinylated

Cat.No. : IKBKB-53H
Product Overview : Recombinant Human IKKβ[1-662 amino acids of accession number NP_001547.1] fused with DYKDDDDK tag at N-terminal was expressed in insect cell and biotinylated.
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  • Gene Information
  • Related Products
Source : Insect cell
Species : Human
Tag : Flag
Form : 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
Molecular Mass : 80 kDa
Purity : >90% as determined by SDS-PAGE and CBB staining
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta [ Homo sapiens ]
Official Symbol : IKBKB
Synonyms : IKBKB; IKK beta; IKK2; IKKB; NFKBIKB; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-beta
Gene ID : 3551
mRNA Refseq : NM_001190720
Protein Refseq : NP_001177649
MIM : 603258
UniProt ID : O14920
Chromosome Location : 8p11.2
Pathway : Activated TLR4 signalling, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem;
Function : ATP binding; IkappaB kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is IKBKB protein involved in inflammatory diseases? 02/24/2023

IKBKB protein is a key regulator of the NF-κB pathway, which plays a central role in the inflammatory response. Dysregulation of IKBKB can contribute to the development of inflammatory diseases.

Can dysregulation of IKBKB protein contribute to neurodegenerative diseases? 11/05/2020

Yes, dysregulation of IKBKB protein and the NF-κB pathway has been implicated in neuroinflammation and the pathogenesis of neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

Is there any potential for targeting IKBKB protein in the treatment of autoimmune diseases? 08/21/2020

Yes, targeting IKBKB protein or the NF-κB pathway is being explored as a potential strategy for treating autoimmune diseases by modulating the inflammatory response.

How is IKBKB protein involved in the regulation of cell survival and apoptosis? 08/28/2019

IKBKB protein activates the NF-κB pathway, which can promote cell survival and inhibit apoptosis in response to various stimuli, making it a potential target for cancer therapy.

Can mutations in the IKBKB gene lead to human diseases? 12/23/2018

Yes, mutations in the IKBKB gene have been associated with immunodeficiency disorders and inflammatory diseases, highlighting the importance of IKBKB protein in immune system function.

Customer Reviews (3)

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Reviews
04/26/2020

    Their team of experts is readily available to assist you with any inquiries or challenges you may encounter during your experiments.

    09/24/2018

      Its purity and functional integrity guarantee optimal performance in a wide range of experimental applications.

      04/13/2016

        This protein, manufactured with utmost precision, provides reliable and consistent results, ensuring the accuracy and reproducibility of your research findings.

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