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Recombinant Human IL17A/IL17F protein, His-tagged

Cat.No. : IL17AF-15H
Product Overview : A DNA sequence encoding the human IL17A (NP_002181.1) (Met1-Ala155) and the mature form of human IL17F (NP_443104.1) (Arg31-Gln163) linked by a polypeptide linker was expressed with a polyhistidine tag at the C-terminus.
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  • Gene Information
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Source : HEK293
Species : Human
Tag : His
Predicted N Terminal : Gly 24
Form : Lyophilized from sterile PBS, pH 7.4.
Molecular Mass : The recombinant human IL17A & IL17F consists 280 amino acids and predicts a molecular mass of 31 kDa.
Endotoxin : <1.0 EU per μg protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade
Storage : Store it under sterile conditions at -20 centigradeto -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : IL17F interleukin 17F [ Homo sapiens ]
Official Symbol : IL17F
Synonyms : IL17F; interleukin 17F; interleukin-17F; IL 17F; ML 1; ML1; IL-24; cytokine ML-1; mutant IL-17F; interleukin-24; ML-1; CANDF6; IL-17F;
Gene ID : 112744
mRNA Refseq : NM_052872
Protein Refseq : NP_443104
MIM : 606496
UniProt ID : Q96PD4
Chromosome Location : 6p12
Pathway : IL23-mediated signaling events, organism-specific biosystem;
Function : cytokine activity; cytokine binding; protein homodimerization activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Could you explain the role of IL17A in autoimmune disease progression using animal models? 05/22/2022

Animal models, such as experimental autoimmune encephalomyelitis, explore IL17A's role in autoimmunity.

Can you detail the protocols for inducing IL17A expression in T cells in vitro? 01/02/2021

Inducing IL17A expression in T cells involves culturing them with specific cytokines.

What strategies elucidate IL17A's impact on tissue-specific inflammation in human samples? 02/17/2020

Studying IL17A's influence on tissue-specific inflammation in humans involves analyzing patient samples.

Can you elaborate on the use of neutralizing antibodies in blocking IL17A's effects? 06/12/2019

Neutralizing antibodies block IL17A's effects in cell cultures or animal models.

How does one perform a multiplex cytokine assay to quantify IL17A along with other cytokines? 12/13/2018

Multiplex cytokine assays use fluorescent beads to measure IL17A and other cytokines simultaneously.

How is the IL17A receptor (IL17RA) signaling pathway activated and studied? 11/23/2018

IL17RA signaling is triggered by IL17A binding and is studied through downstream phosphorylation assays.

What are the methods to investigate the impact of IL17A on epithelial barrier integrity? 08/09/2018

Methods like transepithelial electrical resistance (TEER) assay evaluate IL17A's effect on barrier function.

How is IL17A's contribution to neutrophil recruitment assessed in inflammatory models? 06/25/2018

Inflammatory models, like airway inflammation assays, examine IL17A's impact on neutrophil recruitment.

What techniques are used to analyze IL17A-producing cell populations within a tissue? 06/22/2018

Flow cytometry or intracellular staining help identify IL17A-producing cell subsets within tissues.

What experimental design is employed to understand IL17A's involvement in cancer development? 03/23/2018

Experimental designs combine cancer cell lines with IL17A stimulation to investigate its pro-tumor effects.

Customer Reviews (3)

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Reviews
12/16/2018

    Good for receptor studies.

    03/05/2018

      Effective in Th17 differentiation.

      03/08/2017

        High bioactivity in various tissue types.

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