Recombinant Human IL17B protein, His-tagged
Cat.No. : | IL17B-136H |
Product Overview : | Recombinant Human IL17B(21-180aa) fused with His tag at C-terminal was expressed in Insect cells. |
- Specification
- Gene Information
- Related Products
Description : | IL17B, also known as interleukin-17B isoform 1, is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. It plays a role in inflammation and bone growth. IL-17B binds to IL-17 RB and induces the production of inflammatory cytokines and the infiltration of inflammatory immune cells. |
Source : | Insect cells |
Species : | Human |
Tag : | His |
Form : | Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
Molecular Mass : | 19.2kDa (169aa) 18-28KDa (SDS-PAGE under reducing conditions.) |
AA Sequence : | ADPQPRSPKS KRKGQGRPGP LAPGPHQVPL DLVSRMKPYA RMEEYERNIE EMVAQLRNSS ELAQRKCEVN LQLWMSNKRS LSPWGYSINH DPSRIPVDLP EARCLCLGCV NPFTMQEDRS MVSVPVFSQV PVRRRLCPPP PRTGPCRQRA VMETIAVGCT CIFHHHHHH |
Endotoxin : | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Purity : | > 90% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.25mg/ml (determined by Absorbance at 280nm) |
Gene Name : | IL17B interleukin 17B [ Homo sapiens ] |
Official Symbol : | IL17B |
Synonyms : | IL17B; interleukin 17B; interleukin-17B; IL 17B; IL 20; MGC138900; MGC138901; neuronal interleukin 17 related factor; NIRF; ZCYTO7; interleukin 20; interleukin-20; cytokine Zcyto7; interleukin-17 beta; cytokine-like protein ZCYTO7; neuronal interleukin-17 related factor; neuronal interleukin-17-related factor; IL-20; IL-17B; |
Gene ID : | 27190 |
mRNA Refseq : | NM_014443 |
Protein Refseq : | NP_055258 |
MIM : | 604627 |
UniProt ID : | Q9UHF5 |
Chromosome Location : | 5q33.1 |
Pathway : | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; |
Function : | cytokine activity; |
Products Types
◆ Lysates | ||
IL17B-5244HCL | Recombinant Human IL17B 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionCo-culture experiments and signaling pathway analysis reveal IL17B's interaction with other cytokines.
Techniques like surface plasmon resonance elucidate IL17B's binding to its receptor.
In vivo models combine IL17B overexpression or neutralization with tumor models to study its role.
Human tissue samples are analyzed using immunohistochemistry and cytokine profiling to understand IL17B's effects.
Flow cytometry and functional assays explore how IL17B affects immune cell activation and cytokine production.
Research uses animal models and biomarker analysis to study IL17B in neuroinflammatory diseases.
Genetic techniques like CRISPR/Cas9 knockout or siRNA knockdown validate IL17B's functional impact.
Transwell assays and impedance-based methods evaluate IL17B's impact on endothelial barrier integrity.
Western blotting and phosphorylation assays uncover IL17B's downstream signaling pathways.
Gene expression analysis involves qPCR or RNA sequencing to distinguish IL17B expression patterns.
Customer Reviews (3)
Write a reviewSuitable for signaling studies.
High solubility
Potent in B-cell assays.
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